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1.Basic Information
1.1.Basic Information

name

邱以哲

sex

male

age

55

hospital number

067979

height

170 cm

weight

64 kg

BSA

1.64 m2

APACHEⅡ

20

Infection source

lung

date

年/月/日

Sequential Organ Failure Assessment

Fluid resuscitation

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

coronary atherosclerotic cardiopathy

no

no

no

yes

no

2.T0
1.

yes

斯沃、舒普深、卡泊芬净

vasoactive agent

norepinephrine

20 min

20 min

20 min

2.vital signs

Temperature

36.8

Heart Rate

124 次/分

Breath

23 次/分

Systolic pressure (SP)

143 mmHg

Diastolic pressure

46 mmHg

mean arterial pressure

70 mmHg

3.Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

447.6

VO2

253.6

Ca-vO2

61.1

2.3.、arterial blood gas analysis

pH value

7.44

PaO2

130 mmHg

PaCO2

30 mmHg

BE

-3.6 mmol/L(±2.3mmol/L)

SaO2

99 %

Blood lactic acid concentration, LAC

6.2 mmol/L

Oxygenation index (PaO2/FiO2)

325 mmHg

2.3.、Central venous blood gas analysis

pH value

7.37

PcvO2

25 mmHg

PcvCO2

38 mmHg

BE

-3 mmol/L

ScvO2

43 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

no

Norepinephrine Dosage

0 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

0 μg/Kg/min

5.PiCCO parameters

CVP

11 mmHg

cardiac output

4.15 L/min

cardiac index

2.34 L/min/m2

stroke volume

33.5 ml

Stroke Index

18.9 ml/m2

ITBVI

1111 ml/m2

GEDVI

889 ml/m2

EVLWI

9.3 ml/kg

PVPI

1.5

SVRI

2012 DSm2/cm5

CFI

3

GEF

9 %

SVV

32 %

PPV

%

dPmax

2056

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

mm

mm

mm

mm

3.T6
7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

mm

mm

mm

mm

1..Vital Signs

Temperature

37.8

Heart Rate

111 次/分

Breath

25 次/分

Systolic Pressure

133 mmHg

Diastolic Pressure

37 mmHg

Mean Arterial Pressure

59 mmHg

2..Blood Gas Analysis

Pcv-aCO2

15 mmHg

DO2

488.5

VO2

291.5

Ca-vO2

64.4

3.2..、Arterial Blood Gases

PH value

7.47

PaO2

151 mmHg

PaCO2

30 mmHg

BE

-1.6 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

2.8 mmol/L

Oxygenation index (PaO2/FiO2)

377 mmHg

3.2..、Venous Blood Gas

PH value

7.36

PcvO2

24 mmHg

PcvCO2

45 mmHg

BE

-0.1 mmol/L

ScvO2

40 %

3..Vasoactive Agent and Fluid

Volume of input

842 ml

Volume of output

580 ml

Volume of urine

0 ml

Ultrafiltration Volume

500 ml

Norepinephrine Dosage

11 mg

Dopamine Dosage

0 mg

Epinephrine Dosage

0 mg

Pituitrin Dosage

0 U

Dobutamine Dosage

0 mg

Milrinone Dosage

0 mg

Levosimendan

no

4..PiCCO Parameters

CVP

20 mmHg

cardiac output

4.53 L/min

cardiac index

2.56 L/min/m2

stroke volume

40.8 ml

Stroke Index

23.1 ml/m2

ITBVI

1254 ml/m2

GEDVI

1003 ml/m2

EVLWI

10.2 ml/kg

PVPI

1.5

SVRI

1218 DSm2/cm5

CFI

3

GEF

10 %

SVV

20 %

PPV

%

dPmax

2194

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

4.T12
1..Vital Signs

Temperature

38

Heart Rate

113 次/分

Breath

20 次/分

Systolic Pressure

138 mmHg

Diastolic Pressure

52 mmHg

Mean Arterial Pressure

72 mmHg

2..Blood Gas Analysis

Pcv-aCO2

11 mmHg

DO2

457.1

VO2

314.2

Ca-vO2

74.1

4.2..、Arterial Blood Gas

PH value

7.43

PaO2

114 mmHg

PaCO2

33 mmHg

BE

-2.1 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

6.2 mmol/L

Oxygenation index (PaO2/FiO2)

292 mmHg

4.2..、Venous Blood Gas

PH value

7.34

PcvO2

21 mmHg

PcvCO2

44 mmHg

BE

-1.9 mmol/L

ScvO2

31 %

3..Vasoactive Agent and Fluid

Volume of input

1543 ml

Volume of output

1840 ml

Volume of urine

0 ml

Ultrafiltration Volume

1720 ml

Norepinephrine Dosage

23 mg

Dopamine Dosage

0 mg

Epinephrine Dosage

0 mg

Pituitrin Dosage

0 U

Dobutamine Dosage

0 mg

Milrinone Dosage

0 mg

Levosimendan

no

4..PiCCO Parameters

CVP

13 mmHg

cardiac output

4.24 L/min

cardiac index

2.4 L/min/m2

stroke volume

37.5 ml

Stroke Index

21.2 ml/m2

ITBVI

1112 ml/m2

GEDVI

890 ml/m2

EVLWI

9.6 ml/kg

PVPI

1.6

SVRI

1969 DSm2/cm5

CFI

3

GEF

10 %

SVV

24 %

PPV

%

dPmax

2008

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

37

Heart Rate

120 次/分

Breath

25 次/分

Systolic Pressure

158 mmHg

Diastolic Pressure

51 mmHg

Mean Arterial Pressure

76 mmHg

2.Blood Gas Analysis

Pcv-aCO2

16 mmHg

DO2

497.4

VO2

367.1

Ca-vO2

669

5.2.、Arterial Blood Gas

PH value

7.45

PaO2

132 mmHg

PaCO2

32 mmHg

BE

-1.3 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

8.5 mmol/L

Oxygenation index (PaO2/FiO2)

330 mmHg

5.2.、Venous Blood Gas

PH value

7.35

PcvO2

19 mmHg

PcvCO2

48 mmHg

BE

0.4 mmol/L

ScvO2

26 %

3.Vasoactive Agent and Fluid

Volume of input

3576 ml

Volume of output

2970 ml

Volume of urine

0 ml

Ultrafiltration Volume

2820 ml

Norepinephrine Dosage

45 mg

Dopamine Dosage

20 mg

Epinephrine Dosage

0 mg

Pituitrin Dosage

0 U

Dobutamine Dosage

0 mg

Milrinone Dosage

0 mg

Levosimendan

no

4.PiCCO Parameters

CVP

18 mmHg

cardiac output

5.49 L/min

cardiac index

3.1 L/min/m2

stroke volume

45.8 ml

Stroke Index

25.8 ml/m2

ITBVI

1231 ml/m2

GEDVI

985 ml/m2

EVLWI

8.3 ml/kg

PVPI

1.2

SVRI

1495 DSm2/cm5

CFI

3

GEF

11 %

SVV

15 %

PPV

%

dPmax

2473

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

37.3

Heart Rate

105 次/分

Breath

23 次/分

Systolic Pressure

136 mmHg

Diastolic Pressure

45 mmHg

Mean Arterial Pressure

65 mmHg

2.Blood Gas Analysis

Pcv-aCO2

10 mmHg

DO2

342.9

VO2

263.3

Ca-vO2

61.5

6.2.、Arterial Blood Gas

PH value

7.46

PaO2

157 mmHg

PaCO2

32 mmHg

BE

-0.8 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

8.4 mmol/L

Oxygenation index (PaO2/FiO2)

393 mmHg

6.2.、Venous Blood Gas

PH value

7.38

PcvO2

17 mmHg

PcvCO2

42 mmHg

BE

-0.3 mmol/L

ScvO2

23 %

3.Vasoactive Agent and Fluid

Volume of input

7053 ml

Volume of output

6210 ml

Volume of urine

0 ml

Ultrafiltration Volume

5790 ml

Norepinephrine Dosage

90 mg

Dopamine Dosage

45 mg

Epinephrine Dosage

0 mg

Pituitrin Dosage

0 U

Dobutamine Dosage

0 mg

Milrinone Dosage

0 mg

Levosimendan

no

4.PiCCO Parameters

CVP

10 mmHg

cardiac output

4.28 L/min

cardiac index

2.4 L/min/m2

stroke volume

30 ml

Stroke Index

23 ml/m2

ITBVI

1104 ml/m2

GEDVI

884 ml/m2

EVLWI

10.7 ml/kg

PVPI

1.8

SVRI

1290 DSm2/cm5

CFI

3

GEF

10 %

SVV

30 %

PPV

%

dPmax

2162

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

37.4

Heart Rate

107 次/分

Breath

26 次/分

Systolic Pressure

123 mmHg

Diastolic Pressure

37 mmHg

Mean Arterial Pressure

52 mmHg

2.Blood Gas Analysis

Pcv-aCO2

9 mmHg

DO2

236.1

VO2

207.4

Ca-vO2

70.3

7.2.、Arterial Blood Gas

PH value

7.2

PaO2

151 mmHg

PaCO2

24 mmHg

BE

-16.9 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

15 mmol/L

Oxygenation index (PaO2/FiO2)

378 mmHg

7.2.、Venous Blood Gas

PH value

7.11

PcvO2

37 mmHg

PcvCO2

33 mmHg

BE

-17.9 mmol/L

ScvO2

12 %

3.Vasoactive Agent and Fluid

Volume of input

9051 ml

Volume of output

8010 ml

Volume of urine

0 ml

Ultrafiltration Volume

7968 ml

Norepinephrine Dosage

145 mg

Dopamine Dosage

60 mg

Epinephrine Dosage

0 mg

Pituitrin Dosage

0 U

Dobutamine Dosage

0 mg

Milrinone Dosage

0 mg

Levosimendan

no

4.PiCCO Parameters

CVP

18 mmHg

cardiac output

2.95 L/min

cardiac index

1.67 L/min/m2

stroke volume

27.6 ml

Stroke Index

15.6 ml/m2

ITBVI

1055 ml/m2

GEDVI

844 ml/m2

EVLWI

14.4 ml/kg

PVPI

2.8

SVRI

1631 DSm2/cm5

CFI

2

GEF

8 %

SVV

17 %

PPV

%

dPmax

2298

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

13473 pg/ml

BNP

pg/ml

cTNI

0.206 ng/ml

Creatine kinase isoenzyme, CKMB

17.4 U/L

2.Renel Function Indices

Creatinine

88.8 umol/L

Urea nitrogen

9.26 mmol/l

MDRD

60 ml/min/1.73m2

Date of examination

2017/3/29 yyyy-mm-dd

3.Blood Routine Tests

WBC

18.8 X10*9/L

neutrophilic granulocyte percentage

84 %

Hb

81 g/L

CRP

165 mg/L

Procalcitonin, PCT

7.36 ng/ml

Date of test

2017/3/29

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

12

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

8067 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

14.8 U/L

2.Renel Function Indices

Creatinine

73.49 umol/L

Urea nitrogen

6.31 mmol/l

MDRD

77.9 ml/min/1.73m2

3.Blood Routine Tests

WBC

16.4 X10*9/L

neutrophilic granulocyte percentage

86.3 %

Hb

68 g/L

CRP

80.63 mg/L

Procalcitonin, PCT

4.78 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

13

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

10.3 U/L

2.Renel Function Indices

Creatinine

67.34 umol/L

Urea nitrogen

8.23 mmol/L

MDRD

82.7 ml/min/1.73m2

3.Blood Routine Tests

WBC

18.3 X10*9/L

neutrophilic granulocyte percentage

89.4 %

Hb

60 g/L

CRP

73.51 mg/L

Procalcitonin, PCT

4.5 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

12

11.At the end of the study
4.1.

Transfusion of Red Cells

yes

Transfusion of Red Cells

2 U

Plasma infusion

yes

Plasma infusion

200 ml

platelet transfusion

no

platelet transfusion

0 U

APACHEⅡ

20

Complication

no

4.2.prognosis

prognosis

die

28-day mortality

yes

survival time(day)

5

death time

2017/4/2 yyyy/mm/dd

diagnosis of death

MODS

length of stay

5

duration in ICU

5

duration of mechanical ventilation

120 小时

ICU expenses

32560

Continuous Renal Replacement Therapy

yes

Continuous Renal Replacement Therapy

96 小时