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1.Basic Information
1.1.Basic Information

name

陈兆富

sex

male

age

86

hospital number

800596

height

180 cm

weight

65 kg

BSA

1.85 m2

APACHEⅡ

29

Infection source

lung

date

2017.03.11 年/月/日

Sequential Organ Failure Assessment

6

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

septic shock

mechanical ventilation

Early fluid resuscitation

1.3.Exclusion Criteria

age<60

Pregnant woman

advanced malignant tumor

Pulmonary interstitial fibrosis

Serious arrhythmia

Small Tidal Volume Ventilation

Liver failure

Refuse to participate

1.4.Past medical history

Heart disease

2.T0
1.

vasoactive agent

min

min

min

2.vital signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic pressure (SP)

mmHg

Diastolic pressure

mmHg

mean arterial pressure

mmHg

3.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

2.3.、arterial blood gas analysis

pH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L(±2.3mmol/L)

SaO2

%

Blood lactic acid concentration, LAC

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

2.3.、Central venous blood gas analysis

pH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

4.vasoactive agent and fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

ultrafiltration volume

ml

norepinephrine

Norepinephrine Dosage

μg/Kg/min

dopamine

Dopamine Dosage

μg/Kg/min

Dobutamine

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

mm

mm

mm

mm

3.T6
1..Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2..Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

3.2..、Arterial Blood Gases

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

3.2..、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3..Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

mm

mm

mm

mm

4.T12
1..Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2..Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

4.2..、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

4.2..、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3..Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

5.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

5.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

6.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

6.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

7.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

7.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

no

Plasma infusion

ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

29

Complication

no

4.2.prognosis

prognosis

discharge

28-day mortality

yes

survival time(day)

6

death time

2017.03.16 yyyy/mm/dd

diagnosis of death

MODS 肺部感染 呼吸衰竭 心功能不全

length of stay

17

duration in ICU

5

duration of mechanical ventilation

120 小时

ICU expenses

26885

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时