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1.Basic Information
1.1.Basic Information

name

王金老

sex

male

age

70

hospital number

843593

height

175 cm

weight

70 kg

BSA

1.85 m2

APACHEⅡ

38

Infection source

abdominal
/
blood

date

2017.7.2 年/月/日

Sequential Organ Failure Assessment

15

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

yes

yes

2.T0
1.

yes

比阿培南0.6 bid

vasoactive agent

norepinephrine

120 min

140 min

420 min

2.vital signs

Temperature

36.5

Heart Rate

141 次/分

Breath

19 次/分

Systolic pressure (SP)

155 mmHg

Diastolic pressure

85 mmHg

mean arterial pressure

109 mmHg

3.Blood Gas Analysis

Pcv-aCO2

6.6 mmHg

DO2

274

VO2

60

Ca-vO2

31

2.3.、arterial blood gas analysis

pH value

7.23

PaO2

64.5 mmHg

PaCO2

33.6 mmHg

BE

-12.9 mmol/L(±2.3mmol/L)

SaO2

89.6 %

Blood lactic acid concentration, LAC

3.8 mmol/L

Oxygenation index (PaO2/FiO2)

92 mmHg

2.3.、Central venous blood gas analysis

pH value

7.19

PcvO2

43.6 mmHg

PcvCO2

40.2 mmHg

BE

-12.4 mmol/L

ScvO2

70 %

4.vasoactive agent and fluid

Volume of input

1970 ml

Volume of output

1500 ml

Volume of urine

1200 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

25 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

12 mmHg

cardiac output

1.94 L/min

cardiac index

1.05 L/min/m2

stroke volume

13.8 ml

Stroke Index

7.4 ml/m2

ITBVI

868 ml/m2

GEDVI

695 ml/m2

EVLWI

11.4 ml/kg

PVPI

2.5

SVRI

7396 DSm2/cm5

CFI

2

GEF

5 %

SVV

29 %

PPV

%

dPmax

1360

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

2

LUS

6

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

18 mm

IVC(expiratory phase)

11 mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

16 mm

13 mm

13 mm

9 mm

3.T6
7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

23 mm

IVC(expiratory phase)

21 mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

21 mm

20 mm

18 mm

17 mm

1..Vital Signs

Temperature

35.5

Heart Rate

117 次/分

Breath

18 次/分

Systolic Pressure

145 mmHg

Diastolic Pressure

75 mmHg

Mean Arterial Pressure

103 mmHg

2..Blood Gas Analysis

Pcv-aCO2

8.1 mmHg

DO2

777

VO2

204

Ca-vO2

38

3.2..、Arterial Blood Gases

PH value

7.39

PaO2

68.1 mmHg

PaCO2

36.8 mmHg

BE

-2.5 mmol/L

SaO2

94.7 %

Blood Lactic Acid Concentration

3.9 mmol/L

Oxygenation index (PaO2/FiO2)

113 mmHg

3.2..、Venous Blood Gas

PH value

7.34

PcvO2

38 mmHg

PcvCO2

44.9 mmHg

BE

-1.5 mmol/L

ScvO2

69.8 %

3..Vasoactive Agent and Fluid

Volume of input

3153 ml

Volume of output

3188 ml

Volume of urine

750 ml

Ultrafiltration Volume

2258 ml

Norepinephrine Dosage

35 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

15 mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

4 mmHg

cardiac output

5.37 L/min

cardiac index

2.9 L/min/m2

stroke volume

45.9 ml

Stroke Index

24.8 ml/m2

ITBVI

1084 ml/m2

GEDVI

818 ml/m2

EVLWI

13.1 ml/kg

PVPI

2.2

SVRI

2727 DSm2/cm5

CFI

3

GEF

12 %

SVV

13 %

PPV

%

dPmax

1017

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

3

LUS

8

B+ Zone

4.T12
1..Vital Signs

Temperature

35.6

Heart Rate

108 次/分

Breath

18 次/分

Systolic Pressure

155 mmHg

Diastolic Pressure

79 mmHg

Mean Arterial Pressure

109 mmHg

2..Blood Gas Analysis

Pcv-aCO2

2.1 mmHg

DO2

553

VO2

368

Ca-vO2

75

4.2..、Arterial Blood Gas

PH value

7.46

PaO2

36.5 mmHg

PaCO2

32 mmHg

BE

-0.7 mmol/L

SaO2

72.2 %

Blood Lactic Acid Concentration

6 mmol/L

Oxygenation index (PaO2/FiO2)

36 mmHg

4.2..、Venous Blood Gas

PH value

7.38

PcvO2

18 mmHg

PcvCO2

34.1 mmHg

BE

-4.2 mmol/L

ScvO2

24.1 %

3..Vasoactive Agent and Fluid

Volume of input

6258 ml

Volume of output

9414 ml

Volume of urine

3100 ml

Ultrafiltration Volume

7734 ml

Norepinephrine Dosage

125 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

25 mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

10 mmHg

cardiac output

4.88 L/min

cardiac index

2.64 L/min/m2

stroke volume

45.2 ml

Stroke Index

24.4 ml/m2

ITBVI

1048 ml/m2

GEDVI

839 ml/m2

EVLWI

19.7 ml/kg

PVPI

3.5

SVRI

2758 DSm2/cm5

CFI

3

GEF

12 %

SVV

24.4 %

PPV

%

dPmax

1103

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

5

LUS

12

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

21 mm

IVC(expiratory phase)

18 mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

18 mm

16 mm

17 mm

15 mm

5.T24
1.Vital Signs

Temperature

35.2

Heart Rate

90 次/分

Breath

20 次/分

Systolic Pressure

156 mmHg

Diastolic Pressure

77 mmHg

Mean Arterial Pressure

108 mmHg

2.Blood Gas Analysis

Pcv-aCO2

6.8 mmHg

DO2

502

VO2

151

Ca-vO2

40

5.2.、Arterial Blood Gas

PH value

7.5

PaO2

43 mmHg

PaCO2

28.9 mmHg

BE

0.5 mmol/L

SaO2

82.4 %

Blood Lactic Acid Concentration

5.8 mmol/L

Oxygenation index (PaO2/FiO2)

43 mmHg

5.2.、Venous Blood Gas

PH value

7.46

PcvO2

29.6 mmHg

PcvCO2

35.7 mmHg

BE

1.6 mmol/L

ScvO2

57.5 %

3.Vasoactive Agent and Fluid

Volume of input

2948 ml

Volume of output

4164 ml

Volume of urine

200 ml

Ultrafiltration Volume

3894 ml

Norepinephrine Dosage

158 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

35 mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

2 mmHg

cardiac output

3.79 L/min

cardiac index

2.05 L/min/m2

stroke volume

42.1 ml

Stroke Index

22.8 ml/m2

ITBVI

823 ml/m2

GEDVI

658 ml/m2

EVLWI

34.6 ml/kg

PVPI

7.9

SVRI

4137 DSm2/cm5

CFI

3

GEF

14 %

SVV

9 %

PPV

%

dPmax

1103

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

9

LUS

18

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

25 mm

IVC(expiratory phase)

24 mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

21 mm

19 mm

17 mm

16 mm

6.T48
1.Vital Signs

Temperature

35.5

Heart Rate

77 次/分

Breath

20 次/分

Systolic Pressure

143 mmHg

Diastolic Pressure

73 mmHg

Mean Arterial Pressure

100 mmHg

2.Blood Gas Analysis

Pcv-aCO2

5.7 mmHg

DO2

703

VO2

236

Ca-vO2

47

6.2.、Arterial Blood Gas

PH value

7.56

PaO2

50.5 mmHg

PaCO2

27.9 mmHg

BE

3.4 mmol/L

SaO2

89.1 %

Blood Lactic Acid Concentration

4.7 mmol/L

Oxygenation index (PaO2/FiO2)

40 mmHg

6.2.、Venous Blood Gas

PH value

7.5

PcvO2

31 mmHg

PcvCO2

33.6 mmHg

BE

mmol/L

ScvO2

59.2 %

3.Vasoactive Agent and Fluid

Volume of input

4555 ml

Volume of output

7323 ml

Volume of urine

500 ml

Ultrafiltration Volume

6373 ml

Norepinephrine Dosage

186 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

55 mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

4 mmHg

cardiac output

5.07 L/min

cardiac index

2.74 L/min/m2

stroke volume

65.8 ml

Stroke Index

35.6 ml/m2

ITBVI

1250 ml/m2

GEDVI

1001 ml/m2

EVLWI

34 ml/kg

PVPI

6

SVRI

2801 DSm2/cm5

CFI

3

GEF

15 %

SVV

10 %

PPV

%

dPmax

842

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

9

LUS

20

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

22 mm

IVC(expiratory phase)

20 mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

18 mm

16 mm

17 mm

15 mm

7.T72
1.Vital Signs

Temperature

35.2

Heart Rate

93 次/分

Breath

18 次/分

Systolic Pressure

123 mmHg

Diastolic Pressure

59 mmHg

Mean Arterial Pressure

82 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.9 mmHg

DO2

520

VO2

180

Ca-vO2

43.6

7.2.、Arterial Blood Gas

PH value

7.5

PaO2

52.6 mmHg

PaCO2

27.2 mmHg

BE

-0.7 mmol/L

SaO2

87.8 %

Blood Lactic Acid Concentration

2.7 mmol/L

Oxygenation index (PaO2/FiO2)

89 mmHg

7.2.、Venous Blood Gas

PH value

7.46

PcvO2

31.4 mmHg

PcvCO2

31.1 mmHg

BE

-0.7 mmol/L

ScvO2

57.4 %

3.Vasoactive Agent and Fluid

Volume of input

5429 ml

Volume of output

8856 ml

Volume of urine

550 ml

Ultrafiltration Volume

7836 ml

Norepinephrine Dosage

220 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

68 mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

5 mmHg

cardiac output

4.13 L/min

cardiac index

2.23 L/min/m2

stroke volume

24 ml

Stroke Index

2.5 ml/m2

ITBVI

788 ml/m2

GEDVI

631 ml/m2

EVLWI

25.9 ml/kg

PVPI

6.2

SVRI

2758 DSm2/cm5

CFI

3

GEF

16 %

SVV

16 %

PPV

%

dPmax

1109

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

8

LUS

16

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

20 mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

16 mm

7.7.2、

17 mm

15 mm

16 mm

13 mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

6023 pg/ml

BNP

pg/ml

cTNI

0.068 ng/ml

Creatine kinase isoenzyme, CKMB

24 U/L

2.Renel Function Indices

Creatinine

186 umol/L

Urea nitrogen

13 mmol/l

MDRD

32 ml/min/1.73m2

Date of examination

2017.7.2 yyyy-mm-dd

3.Blood Routine Tests

WBC

10.6 X10*9/L

neutrophilic granulocyte percentage

96.2 %

Hb

g/L

CRP

29.59 mg/L

Procalcitonin, PCT

26.92 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

9.Day 2
1.Cardiac Function Indices

NT-proBNP

9584 pg/ml

BNP

pg/ml

cTNI

0.323 ng/ml

Creatine kinase isoenzyme, CKMB

15 U/L

2.Renel Function Indices

Creatinine

104 umol/L

Urea nitrogen

9.9 mmol/l

MDRD

57 ml/min/1.73m2

3.Blood Routine Tests

WBC

8.7 X10*9/L

neutrophilic granulocyte percentage

95.1 %

Hb

g/L

CRP

288.47 mg/L

Procalcitonin, PCT

大于100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

10.Day 3
1.Cardiac Function Indices

NT-proBNP

9997 pg/ml

BNP

pg/ml

cTNI

0.073 ng/ml

Creatine kinase isoenzyme, CKMB

33 U/L

2.Renel Function Indices

Creatinine

79 umol/L

Urea nitrogen

7.5 mmol/L

MDRD

75 ml/min/1.73m2

3.Blood Routine Tests

WBC

14.9 X10*9/L

neutrophilic granulocyte percentage

96.2 %

Hb

g/L

CRP

267.06 mg/L

Procalcitonin, PCT

70.73 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

18

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

yes

Plasma infusion

2400 ml

platelet transfusion

yes

platelet transfusion

10 U

APACHEⅡ

38

Complication

no

4.2.prognosis

prognosis

die

28-day mortality

no

survival time(day)

35

death time

2017.8.7 yyyy/mm/dd

diagnosis of death

MODS 肺部感染 呼吸衰竭 心功能不全

length of stay

15

duration in ICU

15

duration of mechanical ventilation

332 小时

ICU expenses

134947

Continuous Renal Replacement Therapy

yes

Continuous Renal Replacement Therapy

144 小时