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1.Basic Information
1.1.Basic Information

name

俞孟君

sex

male

age

65

hospital number

893829

height

170 cm

weight

65 kg

BSA

1.75 m2

APACHEⅡ

14

Infection source

abdominal

date

2017.7.18 年/月/日

Sequential Organ Failure Assessment

16

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

yes

no

no

no

2.T0
1.

yes

比阿培南0.6 q12h,替考拉宁0.4 qd

vasoactive agent

norepinephrine

60 min

80 min

240 min

2.vital signs

Temperature

37.2

Heart Rate

84 次/分

Breath

15 次/分

Systolic pressure (SP)

136 mmHg

Diastolic pressure

66 mmHg

mean arterial pressure

90 mmHg

3.Blood Gas Analysis

Pcv-aCO2

14.9 mmHg

DO2

462

VO2

187.7

Ca-vO2

47

2.3.、arterial blood gas analysis

pH value

7.31

PaO2

176 mmHg

PaCO2

28.3 mmHg

BE

-11 mmol/L(±2.3mmol/L)

SaO2

99.5 %

Blood lactic acid concentration, LAC

3.4 mmol/L

Oxygenation index (PaO2/FiO2)

440 mmHg

2.3.、Central venous blood gas analysis

pH value

7.2

PcvO2

33.3 mmHg

PcvCO2

43.2 mmHg

BE

-10.5 mmol/L

ScvO2

59 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

10 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

10 mmHg

cardiac output

3.99 L/min

cardiac index

2.28 L/min/m2

stroke volume

47.5 ml

Stroke Index

27.1 ml/m2

ITBVI

614 ml/m2

GEDVI

491 ml/m2

EVLWI

4.5 ml/kg

PVPI

1.3

SVRI

2806 DSm2/cm5

CFI

5

GEF

23 %

SVV

10 %

PPV

%

dPmax

1451

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

3

LUS

5

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

18 mm

IVC(expiratory phase)

12 mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

15 mm

13 mm

12 mm

10 mm

3.T6
1..Vital Signs

Temperature

37.9

Heart Rate

96 次/分

Breath

17 次/分

Systolic Pressure

143 mmHg

Diastolic Pressure

70 mmHg

Mean Arterial Pressure

97 mmHg

2..Blood Gas Analysis

Pcv-aCO2

6.6 mmHg

DO2

544

VO2

127

Ca-vO2

22.5

3.2..、Arterial Blood Gases

PH value

7.35

PaO2

150 mmHg

PaCO2

33.5 mmHg

BE

-6.5 mmol/L

SaO2

99.6 %

Blood Lactic Acid Concentration

2.6 mmol/L

Oxygenation index (PaO2/FiO2)

375 mmHg

3.2..、Venous Blood Gas

PH value

7.31

PcvO2

41.5 mmHg

PcvCO2

40.1 mmHg

BE

-5.5 mmol/L

ScvO2

76 %

3..Vasoactive Agent and Fluid

Volume of input

5934 ml

Volume of output

2350 ml

Volume of urine

1650 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

10 mg

Dopamine Dosage

0 mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

6 mmHg

cardiac output

5.67 L/min

cardiac index

3.24 L/min/m2

stroke volume

59.1 ml

Stroke Index

33.8 ml/m2

ITBVI

690 ml/m2

GEDVI

552 ml/m2

EVLWI

4.1 ml/kg

PVPI

1.6

SVRI

2147 DSm2/cm5

CFI

6

GEF

%

SVV

5 %

PPV

10 %

dPmax

1157

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

2

LUS

3

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

19 mm

IVC(expiratory phase)

17 mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

17 mm

15 mm

15 mm

13 mm

4.T12
1..Vital Signs

Temperature

37.7

Heart Rate

98 次/分

Breath

16 次/分

Systolic Pressure

158 mmHg

Diastolic Pressure

75 mmHg

Mean Arterial Pressure

107 mmHg

2..Blood Gas Analysis

Pcv-aCO2

7.6 mmHg

DO2

511

VO2

104

Ca-vO2

18.5

4.2..、Arterial Blood Gas

PH value

7.36

PaO2

138 mmHg

PaCO2

32 mmHg

BE

-6.6 mmol/L

SaO2

99.6 %

Blood Lactic Acid Concentration

2.6 mmol/L

Oxygenation index (PaO2/FiO2)

345 mmHg

4.2..、Venous Blood Gas

PH value

7.31

PcvO2

46 mmHg

PcvCO2

39.6 mmHg

BE

-6 mmol/L

ScvO2

79.8 %

3..Vasoactive Agent and Fluid

Volume of input

7121 ml

Volume of output

3770 ml

Volume of urine

2700 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

18 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

4 mmHg

cardiac output

5.64 L/min

cardiac index

3.22 L/min/m2

stroke volume

57.6 ml

Stroke Index

32.9 ml/m2

ITBVI

662 ml/m2

GEDVI

530 ml/m2

EVLWI

3.5 ml/kg

PVPI

0.9

SVRI

2630 DSm2/cm5

CFI

6

GEF

26 %

SVV

6 %

PPV

0.9 %

dPmax

1114

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

2

LUS

2

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

18 mm

IVC(expiratory phase)

15 mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

17 mm

15 mm

15 mm

13 mm

5.T24
1.Vital Signs

Temperature

37.6

Heart Rate

101 次/分

Breath

15 次/分

Systolic Pressure

154 mmHg

Diastolic Pressure

75 mmHg

Mean Arterial Pressure

106 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.2 mmHg

DO2

621

VO2

114

Ca-vO2

19.8

5.2.、Arterial Blood Gas

PH value

7.4

PaO2

130 mmHg

PaCO2

34.7 mmHg

BE

-3 mmol/L

SaO2

99.4 %

Blood Lactic Acid Concentration

2.9 mmol/L

Oxygenation index (PaO2/FiO2)

325 mmHg

5.2.、Venous Blood Gas

PH value

7.37

PcvO2

45.5 mmHg

PcvCO2

37.9 mmHg

BE

-3.2 mmol/L

ScvO2

81.3 %

3.Vasoactive Agent and Fluid

Volume of input

1818 ml

Volume of output

1270 ml

Volume of urine

1200 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

12 mmHg

cardiac output

5.76 L/min

cardiac index

3.29 L/min/m2

stroke volume

57 ml

Stroke Index

32.6 ml/m2

ITBVI

614 ml/m2

GEDVI

491 ml/m2

EVLWI

4 ml/kg

PVPI

1.1

SVRI

2284 DSm2/cm5

CFI

7

GEF

27 %

SVV

2 %

PPV

%

dPmax

1000

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

1

LUS

2

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

19 mm

IVC(expiratory phase)

18 mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

16 mm

13 mm

15 mm

13 mm

6.T48
1.Vital Signs

Temperature

37

Heart Rate

92 次/分

Breath

16 次/分

Systolic Pressure

175 mmHg

Diastolic Pressure

82 mmHg

Mean Arterial Pressure

119 mmHg

2.Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

593

VO2

93

Ca-vO2

18.2

6.2.、Arterial Blood Gas

PH value

7.41

PaO2

78.6 mmHg

PaCO2

36.2 mmHg

BE

-1.1 mmol/L

SaO2

96.5 %

Blood Lactic Acid Concentration

1.4 mmol/L

Oxygenation index (PaO2/FiO2)

196.5 mmHg

6.2.、Venous Blood Gas

PH value

7.38

PcvO2

35.6 mmHg

PcvCO2

43.2 mmHg

BE

0.3 mmol/L

ScvO2

63.5 %

3.Vasoactive Agent and Fluid

Volume of input

3218 ml

Volume of output

4100 ml

Volume of urine

3900 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

18 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

10 mmHg

cardiac output

5.11 L/min

cardiac index

2.92 L/min/m2

stroke volume

55.5 ml

Stroke Index

31.7 ml/m2

ITBVI

654 ml/m2

GEDVI

523 ml/m2

EVLWI

3.9 ml/kg

PVPI

1

SVRI

2985 DSm2/cm5

CFI

6

GEF

25 %

SVV

4 %

PPV

%

dPmax

1045

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

2

LUS

2

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

16 mm

IVC(expiratory phase)

13 mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

13 mm

10 mm

10 mm

9 mm

7.T72
1.Vital Signs

Temperature

37.2

Heart Rate

73 次/分

Breath

18 次/分

Systolic Pressure

156 mmHg

Diastolic Pressure

70 mmHg

Mean Arterial Pressure

102 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.9 mmHg

DO2

454

VO2

78.5

Ca-vO2

19.6

7.2.、Arterial Blood Gas

PH value

7.43

PaO2

123 mmHg

PaCO2

35.3 mmHg

BE

-0.4 mmol/L

SaO2

99.3 %

Blood Lactic Acid Concentration

2.3 mmol/L

Oxygenation index (PaO2/FiO2)

410 mmHg

7.2.、Venous Blood Gas

PH value

7.4

PcvO2

46.3 mmHg

PcvCO2

39.2 mmHg

BE

-0.1 mmol/L

ScvO2

82.6 %

3.Vasoactive Agent and Fluid

Volume of input

2589 ml

Volume of output

3201 ml

Volume of urine

1580 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

18 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

19 mmHg

cardiac output

4.01 L/min

cardiac index

2.17 L/min/m2

stroke volume

48.7 ml

Stroke Index

29.7 ml/m2

ITBVI

699 ml/m2

GEDVI

559 ml/m2

EVLWI

3.2 ml/kg

PVPI

0.8

SVRI

3062 DSm2/cm5

CFI

5

GEF

23 %

SVV

8 %

PPV

%

dPmax

976

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

1

LUS

3

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

17 mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

13 mm

7.7.2、

15 mm

12 mm

13 mm

10 mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

224 pg/ml

BNP

pg/ml

cTNI

0.045 ng/ml

Creatine kinase isoenzyme, CKMB

63 U/L

2.Renel Function Indices

Creatinine

90 umol/L

Urea nitrogen

6.5 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

4.1 X10*9/L

neutrophilic granulocyte percentage

87.3 %

Hb

g/L

CRP

105.1 mg/L

Procalcitonin, PCT

大于100 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

16

9.Day 2
1.Cardiac Function Indices

NT-proBNP

1236 pg/ml

BNP

pg/ml

cTNI

0.018 ng/ml

Creatine kinase isoenzyme, CKMB

50 U/L

2.Renel Function Indices

Creatinine

105 umol/L

Urea nitrogen

9.1 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

25.8 X10*9/L

neutrophilic granulocyte percentage

96.4 %

Hb

g/L

CRP

191.93 mg/L

Procalcitonin, PCT

大于100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

10

10.Day 3
1.Cardiac Function Indices

NT-proBNP

2576 pg/ml

BNP

pg/ml

cTNI

0.067 ng/ml

Creatine kinase isoenzyme, CKMB

32 U/L

2.Renel Function Indices

Creatinine

105 umol/L

Urea nitrogen

9.1 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

30 X10*9/L

neutrophilic granulocyte percentage

95.9 %

Hb

g/L

CRP

322.77 mg/L

Procalcitonin, PCT

32.84 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

5

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

yes

Plasma infusion

1200 ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

8

Complication

no

4.2.prognosis

prognosis

improve

28-day mortality

no

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

30

duration in ICU

3

duration of mechanical ventilation

28 小时

ICU expenses

18576

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时