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1.Screening
1.2.Inclusion Criteria
1.3.Exclusion Criteria
2.Baseline
1.Body Parameters

Weight

kg

Height

m

Body Mass Index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist–hip Ratio

blood pressure

mmHg

2.Menstrual Period

Menstruation

次/12月

3.Hairy Score and Acne Score

Modified Ferriman and Gallwey Score

Rosenfield score

4.Oral Glucose Tolerance Test

Fasting Blood Glucose

mmol/l

0.5h postprandial blood glucose

mmol/l

1h postprandial blood glucose

mmol/l

2h postprandial blood glucose

mmol/l

3h postprandial blood glucose

mmol/l

Area under the curve of glucose

5.Insulin Releasing Test

Fasting Insulin

mU/L

0.5h postprandial insulin

mU/L

1h postprandial insulin

mU/L

2h postprandial insulin

mU/L

3h postprandial insulin

mU/L

Area under the curve of insulin

6.Islet Function Evaluation

The homeostasis model assessment of insulin resistance

Insulin Secretion Index

7.Blood Lipid Profile

Total Cholesterol

mmol/l

Triglycerides

mmol/l

Low-density Lipoprotein

mmol/l

High-density lipoprotein

mmol/l

8.Sex Hormones Level

Total Testosterone

nmol/l

Estradiol

nmol/l

Progesterone

nmol/l

Luteinizing Hormone

nmol/l

Follicle Stimulating Hormone

nmol/l

Dehydroepiandrosterone Sulfate

μg/dl

Sex hormone binding globulin

nmol/l

LH/FSH Ratio

Free androgen index

9.Inflammatory Marks

High sensitivity C - reactive protein

mg/L

10.Body Fat Distribution

Android fat mass

%

Total fat mass

%

3.Follow-up 1
1.Body Parameters

Weight

kg

Waist Circumference

cm

Hip Circumference

cm

Body Mass Index

kg/m2

Waist–hip Ratio

2.Adverse Events

3.Urine pregnancy test

Urine pregnancy test or not

Urine pregnancy test(Positive/Negative)

4.Follow-up 2
1.Body Parameters

Weight

kg

Body Mass Index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist–hip Ratio

cm

2.Adverse Events

3.Urine pregnancy test

Urine pregnancy test or not

Urine pregnancy test(Positive/Negative)

5.Follow-up 3
1.Body Parameters

Weight

kg

Body Mass Index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist–hip Ratio

blood pressure

mmHg

2.Menstrual Period

Menstruation

次/3月

3.Hairy Score and Acne Score

Modified Ferriman and Gallwey Score

Rosenfield Score

4.Oral Glucose Tolerance Test

Fasting blood glucose

mmol/l

0.5h postprandial blood glucose

mmol/l

1h postprandial blood glucose

mmol/l

2h postprandial blood glucose

mmol/l

3h postprandial blood glucose

mmol/l

Glucose Area under the Curve

5.Insulin Releasing Test

Fasting Insulin

mU/L

0.5h postprandial insulin

mU/L

1h postprandial insulin

mU/L

2h postprandial insulin

mU/L

3h postprandial insulin

mU/L

Area under the curve of insulin

6.Islet Function Evaluation

The homeostasis model assessment of insulin resistance

Insulin Secretion Index

7.Blood Lipid Profile

Total cholesterol

mmol/l

Triglycerides

mmol/l

Low-density lipoprotein

mmol/l

High-density lipoprotein

mmol/l

8.Sex Hormones Level

Total Testosterone

nmol/l

Estradiol

nmol/l

Progesterone

nmol/l

Luteinizing Hormone

nmol/l

Follicle Stimulating Hormone

nmol/l

Dehydroepiandrosterone sulfate

μg/dl

Sex hormone binding globulin

nmol/l

LH/FSH Ratio

Free androgen index

9.Inflammatory Marks

High sensitivity C - reactive protein

mg/L

10.Body Fat Distribution

Android fat mass

%

Total fat mass

%

11.Urine pregnancy test

Urine pregnancy test or not

6.Follow-up 4
1.Body Parameters

Weight

kg

Height

cm

Body mass index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist-hip Ratio

blood pressure

mmHg

2.Adverse Events
3.Urine pregnancy test

Urine pregnancy test or not

Urine pregnancy test(Positive/Negative)

4.Gynecological color doppler ultrasound

Gynecological color doppler ultrasound or not

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

7.Follow-up 5
1.Body Parameters

Weight

kg

Height

cm

Body mass index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist-hip Ratio

blood pressure

mmHg

2.Adverse Events
3.Urine pregnancy test

Urine pregnancy test or not

Urine pregnancy test(Positive/Negative)

4.Gynecological color doppler ultrasound

Gynecological color doppler ultrasound or not

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

8.Follow-up 6
7.8.1、Body Parameters

Weight

kg

Height

cm

Body mass index

kg/m2

Waist Circumference

cm

Hip Circumference

cm

Waist-hip Ratio

blood pressure

mmHg

7.8.2、Adverse Events
7.8.3、Urine pregnancy test

Urine pregnancy test or not

Urine pregnancy test(Positive/Negative)

7.8.4、Gynecological color doppler ultrasound

Gynecological color doppler ultrasound or not

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

9.Extended visit
7.9.1、Gynecological color doppler ultrasound

Gynecological color doppler ultrasound or not

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not