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1.Screening
1.2.Inclusion Criteria
1.3.Exclusion Criteria
2.Baseline
1.Body Parameters

blood pressure

mmHg

Waist–hip Ratio

Hip Circumference

cm

Waist Circumference

cm

Body Mass Index

kg/m2

Height

m

Weight

kg

2.Menstrual Period

Menstruation

次/12月

3.Hairy Score and Acne Score

Rosenfield score

Modified Ferriman and Gallwey Score

4.Oral Glucose Tolerance Test

Area under the curve of glucose

3h postprandial blood glucose

mmol/l

2h postprandial blood glucose

mmol/l

1h postprandial blood glucose

mmol/l

0.5h postprandial blood glucose

mmol/l

Fasting Blood Glucose

mmol/l

5.Insulin Releasing Test

3h postprandial insulin

mU/L

2h postprandial insulin

mU/L

1h postprandial insulin

mU/L

0.5h postprandial insulin

mU/L

Fasting Insulin

mU/L

Area under the curve of insulin

6.Islet Function Evaluation

Insulin Secretion Index

The homeostasis model assessment of insulin resistance

7.Blood Lipid Profile

Total Cholesterol

mmol/l

High-density lipoprotein

mmol/l

Low-density Lipoprotein

mmol/l

Triglycerides

mmol/l

8.Sex Hormones Level

Sex hormone binding globulin

nmol/l

Free androgen index

Dehydroepiandrosterone Sulfate

μg/dl

LH/FSH Ratio

Follicle Stimulating Hormone

nmol/l

Luteinizing Hormone

nmol/l

Progesterone

nmol/l

Estradiol

nmol/l

Total Testosterone

nmol/l

9.Inflammatory Marks

High sensitivity C - reactive protein

mg/L

10.Body Fat Distribution

Total fat mass

%

Android fat mass

%

3.Follow-up 1
1.Body Parameters

Waist–hip Ratio

Body Mass Index

kg/m2

Hip Circumference

cm

Waist Circumference

cm

Weight

kg

2.Adverse Events

3.Urine pregnancy test

Urine pregnancy test(Positive/Negative)

Urine pregnancy test or not

4.Follow-up 2
1.Body Parameters

Waist Circumference

cm

Body Mass Index

kg/m2

Weight

kg

Waist–hip Ratio

cm

Hip Circumference

cm

2.Adverse Events

3.Urine pregnancy test

Urine pregnancy test(Positive/Negative)

Urine pregnancy test or not

5.Follow-up 3
1.Body Parameters

blood pressure

mmHg

Waist–hip Ratio

Hip Circumference

cm

Waist Circumference

cm

Body Mass Index

kg/m2

Weight

kg

2.Menstrual Period

Menstruation

次/3月

3.Hairy Score and Acne Score

Rosenfield Score

Modified Ferriman and Gallwey Score

4.Oral Glucose Tolerance Test

1h postprandial blood glucose

mmol/l

0.5h postprandial blood glucose

mmol/l

Fasting blood glucose

mmol/l

Glucose Area under the Curve

3h postprandial blood glucose

mmol/l

2h postprandial blood glucose

mmol/l

5.Insulin Releasing Test

Area under the curve of insulin

3h postprandial insulin

mU/L

2h postprandial insulin

mU/L

1h postprandial insulin

mU/L

0.5h postprandial insulin

mU/L

Fasting Insulin

mU/L

6.Islet Function Evaluation

Insulin Secretion Index

The homeostasis model assessment of insulin resistance

7.Blood Lipid Profile

High-density lipoprotein

mmol/l

Low-density lipoprotein

mmol/l

Triglycerides

mmol/l

Total cholesterol

mmol/l

8.Sex Hormones Level

Free androgen index

LH/FSH Ratio

Sex hormone binding globulin

nmol/l

Dehydroepiandrosterone sulfate

μg/dl

Follicle Stimulating Hormone

nmol/l

Luteinizing Hormone

nmol/l

Progesterone

nmol/l

Estradiol

nmol/l

Total Testosterone

nmol/l

9.Inflammatory Marks

High sensitivity C - reactive protein

mg/L

10.Body Fat Distribution

Total fat mass

%

Android fat mass

%

11.Urine pregnancy test

Urine pregnancy test or not

6.Follow-up 4
1.Body Parameters

blood pressure

mmHg

Waist-hip Ratio

Hip Circumference

cm

Waist Circumference

cm

Body mass index

kg/m2

Height

cm

Weight

kg

2.Adverse Events
3.Urine pregnancy test

Urine pregnancy test(Positive/Negative)

Urine pregnancy test or not

4.Gynecological color doppler ultrasound

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

Gynecological color doppler ultrasound or not

7.Follow-up 5
1.Body Parameters

Body mass index

kg/m2

Height

cm

Weight

kg

blood pressure

mmHg

Waist-hip Ratio

Hip Circumference

cm

Waist Circumference

cm

2.Adverse Events
3.Urine pregnancy test

Urine pregnancy test(Positive/Negative)

Urine pregnancy test or not

4.Gynecological color doppler ultrasound

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

Gynecological color doppler ultrasound or not

8.Follow-up 6
7.8.1、Body Parameters

blood pressure

mmHg

Waist-hip Ratio

Hip Circumference

cm

Waist Circumference

cm

Body mass index

kg/m2

Height

cm

Weight

kg

7.8.2、Adverse Events
7.8.3、Urine pregnancy test

Urine pregnancy test(Positive/Negative)

Urine pregnancy test or not

7.8.4、Gynecological color doppler ultrasound

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

Gynecological color doppler ultrasound or not

9.Extended visit
7.9.1、Gynecological color doppler ultrasound

Whether Gestational sac, germ tissue and fetal heartbeat be visible in gynecological color doppler ultrasound or not

Gynecological color doppler ultrasound or not