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1.Basic Information
1.1.Basic Information

name

叶卫兵

sex

male

age

59

hospital number

433630

height

174 cm

weight

75 kg

BSA

1.9 m2

APACHEⅡ

20

Infection source

lung

date

2017/8/24 年/月/日

Sequential Organ Failure Assessment

15

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

no

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

yes

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

no

no

no

no

no

2.T0
1.

yes

斯沃+美罗培南

vasoactive agent

norepinephrine

120 min

min

720 min

2.vital signs

Temperature

38.5

Heart Rate

128 次/分

Breath

18 次/分

Systolic pressure (SP)

180 mmHg

Diastolic pressure

98 mmHg

mean arterial pressure

127 mmHg

3.Blood Gas Analysis

Pcv-aCO2

15.7 mmHg

DO2

1044.0

VO2

169.1

Ca-vO2

21.8

2.3.、arterial blood gas analysis

pH value

7.29

PaO2

76.2 mmHg

PaCO2

28.2 mmHg

BE

-11.8 mmol/L(±2.3mmol/L)

SaO2

96.5 %

Blood lactic acid concentration, LAC

8 mmol/L

Oxygenation index (PaO2/FiO2)

127 mmHg

2.3.、Central venous blood gas analysis

pH value

7.24

PcvO2

48.1 mmHg

PcvCO2

43.9 mmHg

BE

-8.1 mmol/L

ScvO2

80.9 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.07 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

14 mmHg

cardiac output

7.75 L/min

cardiac index

4.08 L/min/m2

stroke volume

60.5 ml

Stroke Index

3.19 ml/m2

ITBVI

1035 ml/m2

GEDVI

808 ml/m2

EVLWI

8.2 ml/kg

PVPI

1.4

SVRI

2215 DSm2/cm5

CFI

5.1

GEF

16 %

SVV

9 %

PPV

%

dPmax

1888

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

8

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.1 mm

respiratory variations of inferior vena cavae diameter

15 %

2.8.2.、

1.7 mm

mm

2.0 mm

mm

3.T6
1..Vital Signs

Temperature

38

Heart Rate

90 次/分

Breath

18 次/分

Systolic Pressure

145 mmHg

Diastolic Pressure

84 mmHg

Mean Arterial Pressure

107 mmHg

2..Blood Gas Analysis

Pcv-aCO2

5.8 mmHg

DO2

701.8

VO2

135.9

Ca-vO2

22.7

3.2..、Arterial Blood Gases

PH value

7.39

PaO2

140.2 mmHg

PaCO2

30.6 mmHg

BE

-4.7 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

2.4 mmol/L

Oxygenation index (PaO2/FiO2)

233.7 mmHg

3.2..、Venous Blood Gas

PH value

7.37

PcvO2

47.3 mmHg

PcvCO2

36.4 mmHg

BE

-4.2 mmol/L

ScvO2

80.2 %

3..Vasoactive Agent and Fluid

Volume of input

1.34 ml

Volume of output

310 ml

Volume of urine

310 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

8 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

15 mmHg

cardiac output

5.99 L/min

cardiac index

3.15 L/min/m2

stroke volume

66.6 ml

Stroke Index

35 ml/m2

ITBVI

930 ml/m2

GEDVI

744 ml/m2

EVLWI

6.3 ml/kg

PVPI

1.3

SVRI

2333 DSm2/cm5

CFI

4.3

GEF

20 %

SVV

8 %

PPV

/ %

dPmax

13.2

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.2 mm

Respiratory variations of inferior vena cavae diameter

20 %

3.7..2、

1.7 mm

mm

2.1 mm

mm

4.T12
1..Vital Signs

Temperature

37.6

Heart Rate

79 次/分

Breath

18 次/分

Systolic Pressure

116 mmHg

Diastolic Pressure

72 mmHg

Mean Arterial Pressure

89 mmHg

2..Blood Gas Analysis

Pcv-aCO2

10.6 mmHg

DO2

451.8

VO2

9.17

Ca-vO2

2.09

4.2..、Arterial Blood Gas

PH value

7.45

PaO2

69.1 mmHg

PaCO2

34.3 mmHg

BE

-0.6 mmol/L

SaO2

87.5 %

Blood Lactic Acid Concentration

2 mmol/L

Oxygenation index (PaO2/FiO2)

125.6 mmHg

4.2..、Venous Blood Gas

PH value

7.45

PcvO2

37.7 mmHg

PcvCO2

44.9 mmHg

BE

6.1 mmol/L

ScvO2

85.8 %

3..Vasoactive Agent and Fluid

Volume of input

2100 ml

Volume of output

600 ml

Volume of urine

600 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

18 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

15 mmHg

cardiac output

4.73 L/min

cardiac index

2.49 L/min/m2

stroke volume

59.9 ml

Stroke Index

2.49 ml/m2

ITBVI

843 ml/m2

GEDVI

674 ml/m2

EVLWI

5.7 ml/kg

PVPI

1.3

SVRI

2377 DSm2/cm5

CFI

3.8

GEF

20 %

SVV

7 %

PPV

/ %

dPmax

687

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

1.6 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

22 %

4.7..2、

1.5 mm

mm

2.0 mm

mm

5.T24
1.Vital Signs

Temperature

38.3

Heart Rate

76 次/分

Breath

18 次/分

Systolic Pressure

152 mmHg

Diastolic Pressure

92 mmHg

Mean Arterial Pressure

115 mmHg

2.Blood Gas Analysis

Pcv-aCO2

9.4 mmHg

DO2

447.0

VO2

52.8

Ca-vO2

12.0

5.2.、Arterial Blood Gas

PH value

7.44

PaO2

76.9 mmHg

PaCO2

35.5 mmHg

BE

-0.3 mmol/L

SaO2

97.2 %

Blood Lactic Acid Concentration

2 mmol/L

Oxygenation index (PaO2/FiO2)

170.8 mmHg

5.2.、Venous Blood Gas

PH value

7.44

PcvO2

37.7 mmHg

PcvCO2

44.9 mmHg

BE

6.1 mmol/L

ScvO2

85.8 %

3.Vasoactive Agent and Fluid

Volume of input

4136 ml

Volume of output

1250 ml

Volume of urine

1250 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

32 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

15 mmHg

cardiac output

4.39 L/min

cardiac index

2.31 L/min/m2

stroke volume

57.8 ml

Stroke Index

2.31 ml/m2

ITBVI

846 ml/m2

GEDVI

677 ml/m2

EVLWI

6.0 ml/kg

PVPI

1.3

SVRI

3461 DSm2/cm5

CFI

3.5

GEF

19 %

SVV

3 %

PPV

/ %

dPmax

793

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

10 %

5.7.2、

1.8 mm

mm

2.0 mm

mm

6.T48
1.Vital Signs

Temperature

19

Heart Rate

79 次/分

Breath

18 次/分

Systolic Pressure

162 mmHg

Diastolic Pressure

93 mmHg

Mean Arterial Pressure

118 mmHg

2.Blood Gas Analysis

Pcv-aCO2

8.1 mmHg

DO2

714.6

VO2

134.8

Ca-vO2

19.9

6.2.、Arterial Blood Gas

PH value

7.42

PaO2

86.7 mmHg

PaCO2

37.2 mmHg

BE

-0.2 mmol/L

SaO2

97.3 %

Blood Lactic Acid Concentration

3.4 mmol/L

Oxygenation index (PaO2/FiO2)

192.7 mmHg

6.2.、Venous Blood Gas

PH value

7.41

PcvO2

50.3 mmHg

PcvCO2

45.3 mmHg

BE

2.0 mmol/L

ScvO2

79 %

3.Vasoactive Agent and Fluid

Volume of input

7840 ml

Volume of output

315 ml

Volume of urine

315 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

48 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

14 mmHg

cardiac output

6.95 L/min

cardiac index

3.66 L/min/m2

stroke volume

88 ml

Stroke Index

46.3 ml/m2

ITBVI

990 ml/m2

GEDVI

792 ml/m2

EVLWI

5.2 ml/kg

PVPI

1.0

SVRI

2273 DSm2/cm5

CFI

48

GEF

25 %

SVV

6 %

PPV

/ %

dPmax

599

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

1.7 mm

IVC(expiratory phase)

2.3 mm

Respiratory variations of inferior vena cavae diameter

30 %

6.7.2、

1.8 mm

mm

2.4 mm

mm

7.T72
1.Vital Signs

Temperature

37.8

Heart Rate

77 次/分

Breath

18 次/分

Systolic Pressure

144 mmHg

Diastolic Pressure

85 mmHg

Mean Arterial Pressure

105 mmHg

2.Blood Gas Analysis

Pcv-aCO2

9.5 mmHg

DO2

628.3

VO2

204.6

Ca-vO2

32.1

7.2.、Arterial Blood Gas

PH value

7.43

PaO2

97 mmHg

PaCO2

38.4 mmHg

BE

1 mmol/L

SaO2

97.1 %

Blood Lactic Acid Concentration

3.4 mmol/L

Oxygenation index (PaO2/FiO2)

215.6 mmHg

7.2.、Venous Blood Gas

PH value

7.38

PcvO2

28.8 mmHg

PcvCO2

47.5 mmHg

BE

3 mmol/L

ScvO2

66 %

3.Vasoactive Agent and Fluid

Volume of input

11312 ml

Volume of output

5850 ml

Volume of urine

5850 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

82 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

10 mmHg

cardiac output

6.38 L/min

cardiac index

3.36 L/min/m2

stroke volume

82.9 ml

Stroke Index

43.6 ml/m2

ITBVI

95.7 ml/m2

GEDVI

766 ml/m2

EVLWI

5.5 ml/kg

PVPI

1.1

SVRI

2286 DSm2/cm5

CFI

4.5

GEF

25 %

SVV

5 %

PPV

/ %

dPmax

510

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

2.0 %

IVC(inspiratory phase)

22 mm

7.7.2、

1.7 mm

mm

2.0 mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

1663 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

173 umol/L

Urea nitrogen

8.7 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

15.2 X10*9/L

neutrophilic granulocyte percentage

95.9 %

Hb

104 g/L

CRP

341.22 mg/L

Procalcitonin, PCT

大于100 ng/ml

Date of test

2017/8/24

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

791 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

100 umol/L

Urea nitrogen

5.7 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

10.2 X10*9/L

neutrophilic granulocyte percentage

95.3 %

Hb

88 g/L

CRP

338.42 mg/L

Procalcitonin, PCT

67.85 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

13

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

1892 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

100 umol/L

Urea nitrogen

6.4 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

12.7 X10*9/L

neutrophilic granulocyte percentage

96.5 %

Hb

81 g/L

CRP

305.37 mg/L

Procalcitonin, PCT

61.41 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

12

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

no

Plasma infusion

ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

18

Complication

4.2.prognosis

prognosis

discharge

28-day mortality

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

18

duration in ICU

12

duration of mechanical ventilation

288 小时

ICU expenses

133738

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时