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1.Basic Information
1.1.Basic Information

name

张有

sex

male

age

48

hospital number

537905

height

170 cm

weight

70 kg

BSA

1.81 m2

APACHEⅡ

34

Infection source

lung
/
blood

date

2017/12/21 年/月/日

Sequential Organ Failure Assessment

15

Fluid resuscitation

1.2.Inclusion Criteria

age>=60

no

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

yes

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

yes

no

no

no

2.T0
1.

yes

比阿培南+万古霉素

vasoactive agent

norepinephrine
/
dopamine
/
epinephrine

120 min

min

1620 min

2.vital signs

Temperature

36.8

Heart Rate

87 次/分

Breath

16 次/分

Systolic pressure (SP)

152 mmHg

Diastolic pressure

81 mmHg

mean arterial pressure

96 mmHg

3.Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

790.4

VO2

242.5

Ca-vO2

52.5

2.3.、arterial blood gas analysis

pH value

7.2

PaO2

122 mmHg

PaCO2

35 mmHg

BE

-13.2 mmol/L(±2.3mmol/L)

SaO2

98 %

Blood lactic acid concentration, LAC

3.8 mmol/L

Oxygenation index (PaO2/FiO2)

203.3 mmHg

2.3.、Central venous blood gas analysis

pH value

7.16

PcvO2

448 mmHg

PcvCO2

43 mmHg

BE

-12.7 mmol/L

ScvO2

68 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

10 μg/Kg/min

dopamine

yes

Dopamine Dosage

20 μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

Epinephrine

5.PiCCO parameters

CVP

20 mmHg

cardiac output

4.62 L/min

cardiac index

2.55 L/min/m2

stroke volume

53.1 ml

Stroke Index

29.1 ml/m2

ITBVI

794 ml/m2

GEDVI

635 ml/m2

EVLWI

8.4 ml/kg

PVPI

1.9

SVRI

2387 DSm2/cm5

CFI

4.1

GEF

19 %

SVV

%

PPV

%

dPmax

17.4

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

56

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

2.4 mm

IVC(expiratory phase)

2.45 mm

respiratory variations of inferior vena cavae diameter

2 %

2.8.2.、

2.4 mm

mm

2.5 mm

mm

3.T6
1..Vital Signs

Temperature

36.8

Heart Rate

80 次/分

Breath

16 次/分

Systolic Pressure

153 mmHg

Diastolic Pressure

79 mmHg

Mean Arterial Pressure

95 mmHg

2..Blood Gas Analysis

Pcv-aCO2

6 mmHg

DO2

738.4

VO2

196.4

Ca-vO2

40.2

3.2..、Arterial Blood Gases

PH value

7.37

PaO2

96 mmHg

PaCO2

35 mmHg

BE

-4.6 mmol/L

SaO2

98 %

Blood Lactic Acid Concentration

6.6 mmol/L

Oxygenation index (PaO2/FiO2)

160 mmHg

3.2..、Venous Blood Gas

PH value

7.32

PcvO2

39 mmHg

PcvCO2

41 mmHg

BE

-4.4 mmol/L

ScvO2

72 %

3..Vasoactive Agent and Fluid

Volume of input

1130 ml

Volume of output

1500 ml

Volume of urine

60 ml

Ultrafiltration Volume

1200 ml

Norepinephrine Dosage

32 mg

Dopamine Dosage

360 mg

Epinephrine Dosage

5 mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

15 mmHg

cardiac output

4.88 L/min

cardiac index

2.7 L/min/m2

stroke volume

61 ml

Stroke Index

2.7 ml/m2

ITBVI

807 ml/m2

GEDVI

646 ml/m2

EVLWI

6.5 ml/kg

PVPI

1.5

SVRI

2373 DSm2/cm5

CFI

4.3

GEF

22 %

SVV

11 %

PPV

%

dPmax

1958

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

28

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

2.2 mm

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

8.6 %

3.7..2、

2.0 mm

mm

2.2 mm

mm

4.T12
1..Vital Signs

Temperature

36.6

Heart Rate

93 次/分

Breath

16 次/分

Systolic Pressure

117 mmHg

Diastolic Pressure

54 mmHg

Mean Arterial Pressure

69 mmHg

2..Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

959.5

VO2

216.1

Ca-vO2

32.3

4.2..、Arterial Blood Gas

PH value

7.43

PaO2

96 mmHg

PaCO2

36 mmHg

BE

-0.4 mmol/L

SaO2

98 %

Blood Lactic Acid Concentration

5.8 mmol/L

Oxygenation index (PaO2/FiO2)

160 mmHg

4.2..、Venous Blood Gas

PH value

7.38

PcvO2

40 mmHg

PcvCO2

43 mmHg

BE

-0.3 mmol/L

ScvO2

76 %

3..Vasoactive Agent and Fluid

Volume of input

2260 ml

Volume of output

3020 ml

Volume of urine

120 ml

Ultrafiltration Volume

2400 ml

Norepinephrine Dosage

60 mg

Dopamine Dosage

720 mg

Epinephrine Dosage

10 mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

18 mmHg

cardiac output

6.69 L/min

cardiac index

3.7 L/min/m2

stroke volume

71.9 ml

Stroke Index

39.7 ml/m2

ITBVI

824 ml/m2

GEDVI

659 ml/m2

EVLWI

7.0 ml/kg

PVPI

1.6

SVRI

1103 DSm2/cm5

CFI

5.7

GEF

25 %

SVV

8 %

PPV

%

dPmax

1814

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

46

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

2.0 mm

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

18 %

4.7..2、

2.0 mm

mm

2.2 mm

mm

5.T24
1.Vital Signs

Temperature

36.6

Heart Rate

99 次/分

Breath

16 次/分

Systolic Pressure

112 mmHg

Diastolic Pressure

65 mmHg

Mean Arterial Pressure

77 mmHg

2.Blood Gas Analysis

Pcv-aCO2

10 mmHg

DO2

560.6

VO2

113.9

Ca-vO2

26

5.2.、Arterial Blood Gas

PH value

7.46

PaO2

118 mmHg

PaCO2

42 mmHg

BE

5.3 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

2.9 mmol/L

Oxygenation index (PaO2/FiO2)

236 mmHg

5.2.、Venous Blood Gas

PH value

7.4

PcvO2

43 mmHg

PcvCO2

52 mmHg

BE

6.1 mmol/L

ScvO2

79 %

3.Vasoactive Agent and Fluid

Volume of input

4520 ml

Volume of output

6130 ml

Volume of urine

230 ml

Ultrafiltration Volume

4800 ml

Norepinephrine Dosage

100 mg

Dopamine Dosage

1200 mg

Epinephrine Dosage

20 mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

8 mmHg

cardiac output

4.39 L/min

cardiac index

2.43 L/min/m2

stroke volume

44.3 ml

Stroke Index

24.5 ml/m2

ITBVI

495 ml/m2

GEDVI

397 ml/m2

EVLWI

4.5 ml/kg

PVPI

1.7

SVRI

2275 DSm2/cm5

CFI

6.2

GEF

26 %

SVV

11 %

PPV

%

dPmax

1337

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

16

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.2 mm

Respiratory variations of inferior vena cavae diameter

20 %

5.7.2、

1.6 mm

mm

2.0 mm

mm

6.T48
1.Vital Signs

Temperature

36.6

Heart Rate

94 次/分

Breath

18 次/分

Systolic Pressure

123 mmHg

Diastolic Pressure

69 mmHg

Mean Arterial Pressure

83 mmHg

2.Blood Gas Analysis

Pcv-aCO2

6 mmHg

DO2

782.4

VO2

258.4

Ca-vO2

35

6.2.、Arterial Blood Gas

PH value

7.46

PaO2

72 mmHg

PaCO2

37 mmHg

BE

2.5 mmol/L

SaO2

94 %

Blood Lactic Acid Concentration

2.5 mmol/L

Oxygenation index (PaO2/FiO2)

144 mmHg

6.2.、Venous Blood Gas

PH value

7.42

PcvO2

34 mmHg

PcvCO2

43 mmHg

BE

2.8 mmol/L

ScvO2

63 %

3.Vasoactive Agent and Fluid

Volume of input

9292 ml

Volume of output

10070 ml

Volume of urine

370 ml

Ultrafiltration Volume

8400 ml

Norepinephrine Dosage

200 mg

Dopamine Dosage

1800 mg

Epinephrine Dosage

20 mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

14 mmHg

cardiac output

7.38 L/min

cardiac index

4.08 L/min/m2

stroke volume

78.5 ml

Stroke Index

43.4 ml/m2

ITBVI

811 ml/m2

GEDVI

649 ml/m2

EVLWI

8.2 ml/kg

PVPI

1.8

SVRI

1353 DSm2/cm5

CFI

6.4

GEF

28 %

SVV

21 %

PPV

%

dPmax

1633

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

70

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

2.0 mm

IVC(expiratory phase)

2.3 mm

Respiratory variations of inferior vena cavae diameter

14 %

6.7.2、

2.1 mm

mm

2.3 mm

mm

7.T72
1.Vital Signs

Temperature

37.2

Heart Rate

137 次/分

Breath

16 次/分

Systolic Pressure

135 mmHg

Diastolic Pressure

87 mmHg

Mean Arterial Pressure

104 mmHg

2.Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

796.1

VO2

76

Ca-vO2

10.2

7.2.、Arterial Blood Gas

PH value

7.43

PaO2

72 mmHg

PaCO2

42 mmHg

BE

3.1 mmol/L

SaO2

95 %

Blood Lactic Acid Concentration

1.7 mmol/L

Oxygenation index (PaO2/FiO2)

144 mmHg

7.2.、Venous Blood Gas

PH value

7.38

PcvO2

38 mmHg

PcvCO2

50 mmHg

BE

-7.9 mmol/L

ScvO2

86 %

3.Vasoactive Agent and Fluid

Volume of input

12666 ml

Volume of output

14760 ml

Volume of urine

530 ml

Ultrafiltration Volume

12000 ml

Norepinephrine Dosage

280 mg

Dopamine Dosage

2600 mg

Epinephrine Dosage

20 mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

8 mmHg

cardiac output

7.43 L/min

cardiac index

4.1 L/min/m2

stroke volume

54.2 ml

Stroke Index

30.0 ml/m2

ITBVI

1135 ml/m2

GEDVI

908 ml/m2

EVLWI

10.7 ml/kg

PVPI

1.7

SVRI

1870 DSm2/cm5

CFI

4.6

GEF

15 %

SVV

%

PPV

%

dPmax

984

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

72

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

2.4 %

IVC(inspiratory phase)

0 mm

7.7.2、

2.5 mm

mm

2.5 mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

830 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

342 umol/L

Urea nitrogen

15.2 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

8.1 X10*9/L

neutrophilic granulocyte percentage

87.8 %

Hb

130 g/L

CRP

122.64 mg/L

Procalcitonin, PCT

大于100 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

901 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

303 umol/L

Urea nitrogen

12 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

14.9 X10*9/L

neutrophilic granulocyte percentage

90.2 %

Hb

96 g/L

CRP

357.53 mg/L

Procalcitonin, PCT

大于100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

431 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

291 umol/L

Urea nitrogen

9.4 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

11.7 X10*9/L

neutrophilic granulocyte percentage

88.4 %

Hb

84 g/L

CRP

351.21 mg/L

Procalcitonin, PCT

大于100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

yes

Plasma infusion

1000 ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

34

Complication

4.2.prognosis

prognosis

die

28-day mortality

yes

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

5

duration in ICU

5

duration of mechanical ventilation

120 小时

ICU expenses

56710

Continuous Renal Replacement Therapy

yes

Continuous Renal Replacement Therapy

400 小时