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1.Basic Information
1.1.Basic Information

name

周宏富

sex

male

age

80

hospital number

517854

height

176 cm

weight

60 kg

BSA

1.74 m2

APACHEⅡ

22

Infection source

abdominal

date

2017/07/05 年/月/日

Sequential Organ Failure Assessment

20

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

yes

2.T0
1.

yes

泰能+斯沃

vasoactive agent

norepinephrine

30 min

min

30 min

2.vital signs

Temperature

36.9

Heart Rate

123 次/分

Breath

26 次/分

Systolic pressure (SP)

136 mmHg

Diastolic pressure

61 mmHg

mean arterial pressure

86 mmHg

3.Blood Gas Analysis

Pcv-aCO2

12.3 mmHg

DO2

759.8

VO2

256.5

Ca-vO2

53.3

2.3.、arterial blood gas analysis

pH value

7.31

PaO2

128.6 mmHg

PaCO2

30.7 mmHg

BE

-9.6 mmol/L(±2.3mmol/L)

SaO2

98 %

Blood lactic acid concentration, LAC

4.5 mmol/L

Oxygenation index (PaO2/FiO2)

285.8 mmHg

2.3.、Central venous blood gas analysis

pH value

7.30

PcvO2

42 mmHg

PcvCO2

43 mmHg

BE

-10.6 mmol/L

ScvO2

65 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.75 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

3 mmHg

cardiac output

4.81 L/min

cardiac index

2.76 L/min/m2

stroke volume

39.1 ml

Stroke Index

22.5 ml/m2

ITBVI

999 ml/m2

GEDVI

794 ml/m2

EVLWI

6.7 ml/kg

PVPI

1.2

SVRI

1880 DSm2/cm5

CFI

3.2

GEF

11 %

SVV

28 %

PPV

%

dPmax

905

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

4

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

1.2 mm

IVC(expiratory phase)

1.6 mm

respiratory variations of inferior vena cavae diameter

28 %

2.8.2.、

1.2 mm

mm

1.65 mm

mm

3.T6
7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

1.4 mm

IVC(expiratory phase)

1.6 mm

Respiratory variations of inferior vena cavae diameter

13 %

3.7..2、

1.6 mm

mm

1.8 mm

mm

1..Vital Signs

Temperature

37.5

Heart Rate

130 次/分

Breath

20 次/分

Systolic Pressure

100 mmHg

Diastolic Pressure

55 mmHg

Mean Arterial Pressure

66 mmHg

2..Blood Gas Analysis

Pcv-aCO2

11.7 mmHg

DO2

843.2

VO2

269.9

Ca-vO2

47.9

3.2..、Arterial Blood Gases

PH value

7.27

PaO2

97 mmHg

PaCO2

28.3 mmHg

BE

-12.6 mmol/L

SaO2

97 %

Blood Lactic Acid Concentration

7.9 mmol/L

Oxygenation index (PaO2/FiO2)

215.6 mmHg

3.2..、Venous Blood Gas

PH value

7.25

PcvO2

39 mmHg

PcvCO2

40 mmHg

BE

-13 mmol/L

ScvO2

66 %

3..Vasoactive Agent and Fluid

Volume of input

2450 ml

Volume of output

800 ml

Volume of urine

0 ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

16.2 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

7 mmHg

cardiac output

5.63 L/min

cardiac index

3.24 L/min/m2

stroke volume

43.3 ml

Stroke Index

24.9 ml/m2

ITBVI

1078 ml/m2

GEDVI

862 ml/m2

EVLWI

7.6 ml/kg

PVPI

1.3

SVRI

1878 DSm2/cm5

CFI

3.5

GEF

10 %

SVV

%

PPV

%

dPmax

1483

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

4

LUS

B+ Zone

4.T12
1..Vital Signs

Temperature

38

Heart Rate

132 次/分

Breath

20 次/分

Systolic Pressure

130 mmHg

Diastolic Pressure

71 mmHg

Mean Arterial Pressure

92 mmHg

2..Blood Gas Analysis

Pcv-aCO2

9.8 mmHg

DO2

1253.8

VO2

372.7

Ca-vO2

45.7

4.2..、Arterial Blood Gas

PH value

7.53

PaO2

107.3 mmHg

PaCO2

32.1 mmHg

BE

-8 mmol/L

SaO2

97.8 %

Blood Lactic Acid Concentration

2.7 mmol/L

Oxygenation index (PaO2/FiO2)

238.4 mmHg

4.2..、Venous Blood Gas

PH value

7.27

PcvO2

36.6 mmHg

PcvCO2

41.9 mmHg

BE

-7.7 mmol/L

ScvO2

68.8 %

3..Vasoactive Agent and Fluid

Volume of input

4900 ml

Volume of output

1535 ml

Volume of urine

200 ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

32.4 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

1 mmHg

cardiac output

8.16 L/min

cardiac index

4.69 L/min/m2

stroke volume

61.8 ml

Stroke Index

4.69 ml/m2

ITBVI

975 ml/m2

GEDVI

780 ml/m2

EVLWI

7.0 ml/kg

PVPI

1.3

SVRI

1500 DSm2/cm5

CFI

5.6

GEF

16 %

SVV

10 %

PPV

%

dPmax

1435

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

12

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

1.4 mm

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

15 %

4.7..2、

1.4 mm

mm

1.8 mm

mm

5.T24
1.Vital Signs

Temperature

38.5

Heart Rate

138 次/分

Breath

16 次/分

Systolic Pressure

141 mmHg

Diastolic Pressure

81 mmHg

Mean Arterial Pressure

111 mmHg

2.Blood Gas Analysis

Pcv-aCO2

9.1 mmHg

DO2

1147.9

VO2

274.7

Ca-vO2

33.4

5.2.、Arterial Blood Gas

PH value

7.31

PaO2

96 mmHg

PaCO2

23.5 mmHg

BE

-12.9 mmol/L

SaO2

97.2 %

Blood Lactic Acid Concentration

4.4 mmol/L

Oxygenation index (PaO2/FiO2)

213.3 mmHg

5.2.、Venous Blood Gas

PH value

7.27

PcvO2

40.8 mmHg

PcvCO2

32.6 mmHg

BE

-11.3 mmol/L

ScvO2

74.0 %

3.Vasoactive Agent and Fluid

Volume of input

6500 ml

Volume of output

2050 ml

Volume of urine

400 ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

65 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

6 mmHg

cardiac output

8.22 L/min

cardiac index

4.72 L/min/m2

stroke volume

59.6 ml

Stroke Index

34.2 ml/m2

ITBVI

1103 ml/m2

GEDVI

882 ml/m2

EVLWI

8.0 ml/kg

PVPI

1.4

SVRI

1794 DSm2/cm5

CFI

5.0

GEF

14 %

SVV

14 %

PPV

%

dPmax

1359

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

12

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

1.6 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

22 %

5.7.2、

1.5 mm

mm

1.9 mm

mm

6.T48
1.Vital Signs

Temperature

38.3

Heart Rate

150 次/分

Breath

18 次/分

Systolic Pressure

101 mmHg

Diastolic Pressure

71 mmHg

Mean Arterial Pressure

84 mmHg

2.Blood Gas Analysis

Pcv-aCO2

4.8 mmHg

DO2

696.5

VO2

199.6

Ca-vO2

33.2

6.2.、Arterial Blood Gas

PH value

7.41

PaO2

112.2 mmHg

PaCO2

33.7 mmHg

BE

-3.0 mmol/L

SaO2

98 %

Blood Lactic Acid Concentration

0.9 mmol/L

Oxygenation index (PaO2/FiO2)

249.3 mmHg

6.2.、Venous Blood Gas

PH value

7.38

PcvO2

50 mmHg

PcvCO2

38.5 mmHg

BE

-3.2 mmol/L

ScvO2

70 %

3.Vasoactive Agent and Fluid

Volume of input

8914 ml

Volume of output

5431 ml

Volume of urine

2300 ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

97.5 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

180 mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

15 mmHg

cardiac output

6.01 L/min

cardiac index

3.45 L/min/m2

stroke volume

40.1 ml

Stroke Index

34.2 ml/m2

ITBVI

1265 ml/m2

GEDVI

10112 ml/m2

EVLWI

7.5 ml/kg

PVPI

1.1

SVRI

1759 DSm2/cm5

CFI

3.2

GEF

9 %

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

16

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

1.6 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

22 %

6.7.2、

1.7 mm

mm

2.0 mm

mm

7.T72
1.Vital Signs

Temperature

38

Heart Rate

86 次/分

Breath

16 次/分

Systolic Pressure

133 mmHg

Diastolic Pressure

71 mmHg

Mean Arterial Pressure

101 mmHg

2.Blood Gas Analysis

Pcv-aCO2

5.3 mmHg

DO2

644.5

VO2

150.8

Ca-vO2

27.7

7.2.、Arterial Blood Gas

PH value

7.45

PaO2

103.1 mmHg

PaCO2

34.7 mmHg

BE

-1.1 mmol/L

SaO2

97.8 %

Blood Lactic Acid Concentration

2.2 mmol/L

Oxygenation index (PaO2/FiO2)

229.1 mmHg

7.2.、Venous Blood Gas

PH value

7.41

PcvO2

44 mmHg

PcvCO2

40 mmHg

BE

-1.2 mmol/L

ScvO2

75 %

3.Vasoactive Agent and Fluid

Volume of input

13300 ml

Volume of output

7476 ml

Volume of urine

4800 ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

97.5 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

360 mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

12 mmHg

cardiac output

5.45 L/min

cardiac index

3.13 L/min/m2

stroke volume

63.4 ml

Stroke Index

36.4 ml/m2

ITBVI

13.8 ml/m2

GEDVI

1055 ml/m2

EVLWI

8.6 ml/kg

PVPI

1.2

SVRI

2553 DSm2/cm5

CFI

2.7

GEF

12 %

SVV

5 %

PPV

%

dPmax

1255

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

28

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

2.0 %

IVC(inspiratory phase)

10 mm

7.7.2、

1.8 mm

mm

2.0 mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

243 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

103 umol/L

Urea nitrogen

10.9 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

2.1 X10*9/L

neutrophilic granulocyte percentage

70.8 %

Hb

120 g/L

CRP

86.78 mg/L

Procalcitonin, PCT

>100 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

20

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

153 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

115 umol/L

Urea nitrogen

13.9 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

15.9 X10*9/L

neutrophilic granulocyte percentage

96.5 %

Hb

107 g/L

CRP

300.5 mg/L

Procalcitonin, PCT

>100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

17

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

565 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

121 umol/L

Urea nitrogen

13.4 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

16.6 X10*9/L

neutrophilic granulocyte percentage

96.6 %

Hb

88 g/L

CRP

285.5 mg/L

Procalcitonin, PCT

>100 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

yes

Plasma infusion

1500 ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

14

Complication

4.2.prognosis

prognosis

department transference

28-day mortality

no

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

duration in ICU

16

duration of mechanical ventilation

312 小时

ICU expenses

191878

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时