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1.Basic Information
1.1.Basic Information

name

丁玉凤

sex

female

age

90

hospital number

528577

height

160 cm

weight

65 kg

BSA

1.62 m2

APACHEⅡ

16

Infection source

other

date

2017/09/30 年/月/日

Sequential Organ Failure Assessment

9

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

yes

2.T0
1.

yes

美罗培南1.0g q8h

vasoactive agent

norepinephrine

180 min

min

10800 min

2.vital signs

Temperature

37

Heart Rate

70 次/分

Breath

18 次/分

Systolic pressure (SP)

167 mmHg

Diastolic pressure

57 mmHg

mean arterial pressure

90 mmHg

3.Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

536.2

VO2

136.4

Ca-vO2

27.4

2.3.、arterial blood gas analysis

pH value

7.42

PaO2

143 mmHg

PaCO2

26 mmHg

BE

-6.7 mmol/L(±2.3mmol/L)

SaO2

99 %

Blood lactic acid concentration, LAC

1.8 mmol/L

Oxygenation index (PaO2/FiO2)

317.8 mmHg

2.3.、Central venous blood gas analysis

pH value

7.37

PcvO2

41 mmHg

PcvCO2

33 mmHg

BE

-5.6 mmol/L

ScvO2

74 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.5 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

8 mmHg

cardiac output

4.97 L/min

cardiac index

3.07 L/min/m2

stroke volume

71.0 ml

Stroke Index

43.8 ml/m2

ITBVI

854 ml/m2

GEDVI

684 ml/m2

EVLWI

7.1 ml/kg

PVPI

1.3

SVRI

2137 DSm2/cm5

CFI

5.2

GEF

29 %

SVV

8 %

PPV

%

dPmax

2293

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

8

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

1.4 mm

IVC(expiratory phase)

1.8 mm

respiratory variations of inferior vena cavae diameter

25 %

2.8.2.、

1.2 mm

mm

1.7 mm

mm

3.T6
1..Vital Signs

Temperature

37.5

Heart Rate

75 次/分

Breath

19 次/分

Systolic Pressure

152 mmHg

Diastolic Pressure

57 mmHg

Mean Arterial Pressure

84 mmHg

2..Blood Gas Analysis

Pcv-aCO2

2 mmHg

DO2

500.9

VO2

96.9

Ca-vO2

21.6

3.2..、Arterial Blood Gases

PH value

7.44

PaO2

129 mmHg

PaCO2

26 mmHg

BE

-5.9 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

1.5 mmol/L

Oxygenation index (PaO2/FiO2)

286.7 mmHg

3.2..、Venous Blood Gas

PH value

7.42

PcvO2

43 mmHg

PcvCO2

28 mmHg

BE

-5.5 mmol/L

ScvO2

80 %

3..Vasoactive Agent and Fluid

Volume of input

1500 ml

Volume of output

500 ml

Volume of urine

355 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

10 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

11 mmHg

cardiac output

4.48 L/min

cardiac index

2.77 L/min/m2

stroke volume

59.7 ml

Stroke Index

36.9 ml/m2

ITBVI

773 ml/m2

GEDVI

619 ml/m2

EVLWI

7.3 ml/kg

PVPI

1.5

SVRI

2111 DSm2/cm5

CFI

5.2

GEF

29 %

SVV

13 %

PPV

%

dPmax

1952

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

8

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

1.4 mm

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

20 %

3.7..2、

1.5 mm

mm

1.9 mm

mm

4.T12
1..Vital Signs

Temperature

36.9

Heart Rate

90 次/分

Breath

17 次/分

Systolic Pressure

164 mmHg

Diastolic Pressure

60 mmHg

Mean Arterial Pressure

95 mmHg

2..Blood Gas Analysis

Pcv-aCO2

4 mmHg

DO2

628.7

VO2

164.8

Ca-vO2

29.6

4.2..、Arterial Blood Gas

PH value

7.45

PaO2

170 mmHg

PaCO2

28 mmHg

BE

-4 mmol/L

SaO2

100 %

Blood Lactic Acid Concentration

1 mmol/L

Oxygenation index (PaO2/FiO2)

377.8 mmHg

4.2..、Venous Blood Gas

PH value

7.43

PcvO2

46 mmHg

PcvCO2

32 mmHg

BE

-5 mmol/L

ScvO2

74 %

3..Vasoactive Agent and Fluid

Volume of input

2570 ml

Volume of output

1800 ml

Volume of urine

1515 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

18 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

5 mmHg

cardiac output

5.56 L/min

cardiac index

3.43 L/min/m2

stroke volume

61.8 ml

Stroke Index

38.1 ml/m2

ITBVI

848 ml/m2

GEDVI

679 ml/m2

EVLWI

2.1 ml/kg

PVPI

7.1

SVRI

2097 DSm2/cm5

CFI

5.8

GEF

26 %

SVV

15 %

PPV

%

dPmax

1877

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

8

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

1.6 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

22 %

4.7..2、

1.6 mm

mm

2.0 mm

mm

5.T24
1.Vital Signs

Temperature

38

Heart Rate

74 次/分

Breath

18 次/分

Systolic Pressure

140 mmHg

Diastolic Pressure

57 mmHg

Mean Arterial Pressure

78 mmHg

2.Blood Gas Analysis

Pcv-aCO2

6 mmHg

DO2

700.8

VO2

135.6

Ca-vO2

25.5

5.2.、Arterial Blood Gas

PH value

7.4

PaO2

135 mmHg

PaCO2

27 mmHg

BE

-6.1 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

1.8 mmol/L

Oxygenation index (PaO2/FiO2)

300 mmHg

5.2.、Venous Blood Gas

PH value

7.38

PcvO2

42 mmHg

PcvCO2

33 mmHg

BE

-5.8 mmol/L

ScvO2

80 %

3.Vasoactive Agent and Fluid

Volume of input

4143 ml

Volume of output

3410 ml

Volume of urine

3030 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

36 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

11 mmHg

cardiac output

5.32 L/min

cardiac index

3.28 L/min/m2

stroke volume

71.9 ml

Stroke Index

44.4 ml/m2

ITBVI

893 ml/m2

GEDVI

714 ml/m2

EVLWI

7.5 ml/kg

PVPI

1.4

SVRI

1631 DSm2/cm5

CFI

5.3

GEF

30 %

SVV

14 %

PPV

%

dPmax

1804

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

12

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

1.6 mm

IVC(expiratory phase)

2.0 mm

Respiratory variations of inferior vena cavae diameter

22 %

5.7.2、

1.6 mm

mm

2.0 mm

mm

6.T48
1.Vital Signs

Temperature

38.5

Heart Rate

97 次/分

Breath

20 次/分

Systolic Pressure

162 mmHg

Diastolic Pressure

75 mmHg

Mean Arterial Pressure

64 mmHg

2.Blood Gas Analysis

Pcv-aCO2

4 mmHg

DO2

433.5

VO2

85.5

Ca-vO2

21.9

6.2.、Arterial Blood Gas

PH value

7.43

PaO2

125 mmHg

PaCO2

33 mmHg

BE

-2.1 mmol/L

SaO2

97 %

Blood Lactic Acid Concentration

1 mmol/L

Oxygenation index (PaO2/FiO2)

312.5 mmHg

6.2.、Venous Blood Gas

PH value

7.40

PcvO2

50 mmHg

PcvCO2

37 mmHg

BE

-1.8 mmol/L

ScvO2

78 %

3.Vasoactive Agent and Fluid

Volume of input

7302 ml

Volume of output

5886 ml

Volume of urine

5330 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

36 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

10 mmHg

cardiac output

3.91 L/min

cardiac index

2.45 L/min/m2

stroke volume

25.3 ml

Stroke Index

40.9 ml/m2

ITBVI

687 ml/m2

GEDVI

550 ml/m2

EVLWI

6.3 ml/kg

PVPI

1.5

SVRI

3067 DSm2/cm5

CFI

5.1

GEF

22 %

SVV

17 %

PPV

%

dPmax

1254

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

12

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.2 mm

Respiratory variations of inferior vena cavae diameter

20 %

6.7.2、

1.7 mm

mm

2.3 mm

mm

7.T72
1.Vital Signs

Temperature

37.5

Heart Rate

82 次/分

Breath

20 次/分

Systolic Pressure

154 mmHg

Diastolic Pressure

88 mmHg

Mean Arterial Pressure

112 mmHg

2.Blood Gas Analysis

Pcv-aCO2

5 mmHg

DO2

847.5

VO2

198.1

Ca-vO2

26.4

7.2.、Arterial Blood Gas

PH value

7.44

PaO2

131 mmHg

PaCO2

32 mmHg

BE

-2.2 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

1.6 mmol/L

Oxygenation index (PaO2/FiO2)

327.5 mmHg

7.2.、Venous Blood Gas

PH value

7.41

PcvO2

48 mmHg

PcvCO2

37 mmHg

BE

-3 mmol/L

ScvO2

76 %

3.Vasoactive Agent and Fluid

Volume of input

7549 ml

Volume of output

7631 ml

Volume of urine

6980 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

36 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

11 mmHg

cardiac output

7.49 L/min

cardiac index

3.94 L/min/m2

stroke volume

91.3 ml

Stroke Index

48.1 ml/m2

ITBVI

915 ml/m2

GEDVI

733 ml/m2

EVLWI

6.3 ml/kg

PVPI

1.2

SVRI

2049 DSm2/cm5

CFI

5.5

GEF

28 %

SVV

9 %

PPV

%

dPmax

626

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

12

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

2.0 %

IVC(inspiratory phase)

10 mm

7.7.2、

1.9 mm

mm

2.0 mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

720 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

79 umol/L

Urea nitrogen

2 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

10.1 X10*9/L

neutrophilic granulocyte percentage

62.3 %

Hb

81 g/L

CRP

42.26 mg/L

Procalcitonin, PCT

4.95 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

9

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

81 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

129 umol/L

Urea nitrogen

4.5 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

10.9 X10*9/L

neutrophilic granulocyte percentage

85.6 %

Hb

99 g/L

CRP

203.9 mg/L

Procalcitonin, PCT

2.7 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

6

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

178 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

65 umol/L

Urea nitrogen

3.4 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

8.3 X10*9/L

neutrophilic granulocyte percentage

75.1 %

Hb

85 g/L

CRP

165 mg/L

Procalcitonin, PCT

1.69 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

6

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

no

Plasma infusion

ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

Complication

4.2.prognosis

prognosis

improve

28-day mortality

no

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

duration in ICU

24

duration of mechanical ventilation

480 小时

ICU expenses

165370

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时