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1.Basic Information
1.1.Basic Information

name

祝鸿俊

sex

male

age

84

hospital number

189380

height

170 cm

weight

70 kg

BSA

1.81 m2

APACHEⅡ

30

Infection source

lung
/
urinary
/
blood
/
skin and soft tissue

date

2017/11/21 年/月/日

Sequential Organ Failure Assessment

13

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

coronary atherosclerotic cardiopathy

yes

no

no

yes

no

2.T0
1.

yes

舒普深 2.0 q6h

vasoactive agent

norepinephrine

30 min

min

43200 min

2.vital signs

Temperature

38

Heart Rate

108 次/分

Breath

17 次/分

Systolic pressure (SP)

130 mmHg

Diastolic pressure

78 mmHg

mean arterial pressure

95 mmHg

3.Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

444.6

VO2

161.0

Ca-vO2

34.6

2.3.、arterial blood gas analysis

pH value

7.46

PaO2

160 mmHg

PaCO2

30 mmHg

BE

-2.1 mmol/L(±2.3mmol/L)

SaO2

100 %

Blood lactic acid concentration, LAC

1.9 mmol/L

Oxygenation index (PaO2/FiO2)

400 mmHg

2.3.、Central venous blood gas analysis

pH value

7.35

PcvO2

34 mmHg

PcvCO2

38 mmHg

BE

-4.2 mmol/L

ScvO2

64 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

10 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

11 mmHg

cardiac output

4.65 L/min

cardiac index

2.57 L/min/m2

stroke volume

48.2 ml

Stroke Index

26.6 ml/m2

ITBVI

936 ml/m2

GEDVI

748 ml/m2

EVLWI

7.1 ml/kg

PVPI

1.4

SVRI

1200 DSm2/cm5

CFI

4.8

GEF

15 %

SVV

13 %

PPV

%

dPmax

1235

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

16

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

2.4 mm

IVC(expiratory phase)

2.5 mm

respiratory variations of inferior vena cavae diameter

4 %

2.8.2.、

2.3 mm

mm

2.4 mm

mm

3.T6
7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

2.2 mm

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

8 %

3.7..2、

2.0 mm

mm

2.3 mm

mm

1..Vital Signs

Temperature

37.8

Heart Rate

112 次/分

Breath

18 次/分

Systolic Pressure

135 mmHg

Diastolic Pressure

65 mmHg

Mean Arterial Pressure

88 mmHg

2..Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

506.7

VO2

137.9

Ca-vO2

26.0

3.2..、Arterial Blood Gases

PH value

7.43

PaO2

152 mmHg

PaCO2

34 mmHg

BE

-0.8 mmol/L

SaO2

100 %

Blood Lactic Acid Concentration

1.6 mmol/L

Oxygenation index (PaO2/FiO2)

380 mmHg

3.2..、Venous Blood Gas

PH value

7.36

PcvO2

39 mmHg

PcvCO2

42 mmHg

BE

-1.3 mmol/L

ScvO2

73 %

3..Vasoactive Agent and Fluid

Volume of input

2028 ml

Volume of output

300 ml

Volume of urine

300 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

8.6 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

13 mmHg

cardiac output

5.3 L/min

cardiac index

2.96 L/min/m2

stroke volume

53.1 ml

Stroke Index

29.2 ml/m2

ITBVI

975 ml/m2

GEDVI

780 ml/m2

EVLWI

7.3 ml/kg

PVPI

1.6

SVRI

1600 DSm2/cm5

CFI

5.0

GEF

14 %

SVV

11 %

PPV

%

dPmax

1240

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

18

LUS

B+ Zone

4.T12
1..Vital Signs

Temperature

37.5

Heart Rate

95 次/分

Breath

18 次/分

Systolic Pressure

128 mmHg

Diastolic Pressure

63 mmHg

Mean Arterial Pressure

84 mmHg

2..Blood Gas Analysis

Pcv-aCO2

8 mmHg

DO2

506.7

VO2

137.9

Ca-vO2

26.0

4.2..、Arterial Blood Gas

PH value

7.41

PaO2

111 mmHg

PaCO2

35 mmHg

BE

-2.1 mmol/L

SaO2

98 %

Blood Lactic Acid Concentration

1.3 mmol/L

Oxygenation index (PaO2/FiO2)

277.5 mmHg

4.2..、Venous Blood Gas

PH value

7.31

PcvO2

38 mmHg

PcvCO2

43 mmHg

BE

-6.3 mmol/L

ScvO2

75 %

3..Vasoactive Agent and Fluid

Volume of input

4056 ml

Volume of output

600 ml

Volume of urine

600 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

24 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

13 mmHg

cardiac output

5.73 L/min

cardiac index

3.16 L/min/m2

stroke volume

61.5 ml

Stroke Index

33.9 ml/m2

ITBVI

900 ml/m2

GEDVI

720 ml/m2

EVLWI

7.1 ml/kg

PVPI

1.6

SVRI

1820 DSm2/cm5

CFI

4.9

GEF

16 %

SVV

10 %

PPV

%

dPmax

1360

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

14

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

2.0 mm

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

18 %

4.7..2、

1.8 mm

mm

2.2 mm

mm

5.T24
1.Vital Signs

Temperature

36.8

Heart Rate

81 次/分

Breath

18 次/分

Systolic Pressure

139 mmHg

Diastolic Pressure

80 mmHg

Mean Arterial Pressure

99 mmHg

2.Blood Gas Analysis

Pcv-aCO2

9 mmHg

DO2

60.3.3

VO2

152.8

Ca-vO2

25.6

5.2.、Arterial Blood Gas

PH value

7.56

PaO2

184 mmHg

PaCO2

33 mmHg

BE

2.9 mmol/L

SaO2

100 %

Blood Lactic Acid Concentration

2.4 mmol/L

Oxygenation index (PaO2/FiO2)

460 mmHg

5.2.、Venous Blood Gas

PH value

7.44

PcvO2

30 mmHg

PcvCO2

42 mmHg

BE

2.4 mmol/L

ScvO2

75 %

3.Vasoactive Agent and Fluid

Volume of input

5556 ml

Volume of output

2100 ml

Volume of urine

800 ml

Ultrafiltration Volume

1300 ml

Norepinephrine Dosage

48 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

10 mg

Levosimendan

no

4.PiCCO Parameters

CVP

12 mmHg

cardiac output

5.97 L/min

cardiac index

3.29 L/min/m2

stroke volume

62.5 ml

Stroke Index

34.5 ml/m2

ITBVI

878 ml/m2

GEDVI

702 ml/m2

EVLWI

6.7 ml/kg

PVPI

1.3

SVRI

1970 DSm2/cm5

CFI

5.1

GEF

17 %

SVV

10 %

PPV

%

dPmax

1410

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

14

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

1.8 mm

IVC(expiratory phase)

2.2 mm

Respiratory variations of inferior vena cavae diameter

20 %

5.7.2、

1.9 mm

mm

2.3 mm

mm

6.T48
1.Vital Signs

Temperature

37.3

Heart Rate

93 次/分

Breath

18 次/分

Systolic Pressure

142 mmHg

Diastolic Pressure

91 mmHg

Mean Arterial Pressure

108 mmHg

2.Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

467.9

VO2

109.9

Ca-vO2

18.5

6.2.、Arterial Blood Gas

PH value

7.47

PaO2

133 mmHg

PaCO2

38 mmHg

BE

1 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

1.3 mmol/L

Oxygenation index (PaO2/FiO2)

310 mmHg

6.2.、Venous Blood Gas

PH value

7.44

PcvO2

30 mmHg

PcvCO2

41 mmHg

BE

303 mmol/L

ScvO2

76 %

3.Vasoactive Agent and Fluid

Volume of input

7147 ml

Volume of output

3457 ml

Volume of urine

850 ml

Ultrafiltration Volume

2657 ml

Norepinephrine Dosage

96 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

30 mg

Levosimendan

4.PiCCO Parameters

CVP

12 mmHg

cardiac output

5.95 L/min

cardiac index

3.28 L/min/m2

stroke volume

61.2 ml

Stroke Index

33.8 ml/m2

ITBVI

875 ml/m2

GEDVI

700 ml/m2

EVLWI

6.6 ml/kg

PVPI

1.3

SVRI

2015 DSm2/cm5

CFI

5.0

GEF

17 %

SVV

12 %

PPV

%

dPmax

1310

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

10

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

2.0 mm

IVC(expiratory phase)

2.4 mm

Respiratory variations of inferior vena cavae diameter

18 %

6.7.2、

1.8 mm

mm

2.3 mm

mm

7.T72
1.Vital Signs

Temperature

37.5

Heart Rate

88 次/分

Breath

18 次/分

Systolic Pressure

125 mmHg

Diastolic Pressure

65 mmHg

Mean Arterial Pressure

85 mmHg

2.Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

432.7

VO2

93.2

Ca-vO2

15.2

7.2.、Arterial Blood Gas

PH value

7.45

PaO2

133 mmHg

PaCO2

38 mmHg

BE

2.2 mmol/L

SaO2

99 %

Blood Lactic Acid Concentration

1.5 mmol/L

Oxygenation index (PaO2/FiO2)

332.5 mmHg

7.2.、Venous Blood Gas

PH value

7.39

PcvO2

30 mmHg

PcvCO2

45 mmHg

BE

3.8 mmol/L

ScvO2

78 %

3.Vasoactive Agent and Fluid

Volume of input

10404 ml

Volume of output

6117 ml

Volume of urine

1080 ml

Ultrafiltration Volume

5037 ml

Norepinephrine Dosage

96 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

30 mg

Levosimendan

4.PiCCO Parameters

CVP

8 mmHg

cardiac output

6.12 L/min

cardiac index

3.38 L/min/m2

stroke volume

63.7 ml

Stroke Index

35.1 ml/m2

ITBVI

830 ml/m2

GEDVI

664 ml/m2

EVLWI

6.3 ml/kg

PVPI

1.2

SVRI

1930 DSm2/cm5

CFI

5.0

GEF

10 %

SVV

11 %

PPV

%

dPmax

1210

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

6

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

1.8 mm

Respiratory variations of inferior vena cavae diameter

2.0 %

IVC(inspiratory phase)

10 mm

7.7.2、

2.0 mm

mm

2.1 mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

1294 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

102 umol/L

Urea nitrogen

8 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

14.3 X10*9/L

neutrophilic granulocyte percentage

71.9 %

Hb

71 g/L

CRP

87.42 mg/L

Procalcitonin, PCT

0.975 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

13

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

658 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

72 umol/L

Urea nitrogen

5.2 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

10.5 X10*9/L

neutrophilic granulocyte percentage

66.8 %

Hb

75 g/L

CRP

79.62 mg/L

Procalcitonin, PCT

1.03 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

13

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

260 pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

71 umol/L

Urea nitrogen

4.2 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

8.9 X10*9/L

neutrophilic granulocyte percentage

68.3 %

Hb

59 g/L

CRP

65.71 mg/L

Procalcitonin, PCT

1.31 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

11

11.At the end of the study
4.1.

Transfusion of Red Cells

Transfusion of Red Cells

U

Plasma infusion

Plasma infusion

ml

platelet transfusion

platelet transfusion

U

APACHEⅡ

Complication

4.2.prognosis

prognosis

28-day mortality

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

duration in ICU

duration of mechanical ventilation

小时

ICU expenses

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

小时