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1.Basic Information
1.1.Basic Information

name

朱妙桂

sex

male

age

71

hospital number

510269

height

170 cm

weight

55 kg

BSA

1.63 m2

APACHEⅡ

17

Infection source

abdominal

date

2017/03/03 年/月/日

Sequential Organ Failure Assessment

6

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

no

no

no

no

no

2.T0
1.

yes

比阿培南+奥硝唑

vasoactive agent

norepinephrine

120 min

min

3600 min

2.vital signs

Temperature

36

Heart Rate

69 次/分

Breath

16 次/分

Systolic pressure (SP)

128 mmHg

Diastolic pressure

61 mmHg

mean arterial pressure

83 mmHg

3.Blood Gas Analysis

Pcv-aCO2

7.1 mmHg

DO2

659.9

VO2

157.0

Ca-vO2

36.3

2.3.、arterial blood gas analysis

pH value

7.33

PaO2

161 mmHg

PaCO2

32.7 mmHg

BE

-7.6 mmol/L(±2.3mmol/L)

SaO2

99 %

Blood lactic acid concentration, LAC

1.6 mmol/L

Oxygenation index (PaO2/FiO2)

357.8 mmHg

2.3.、Central venous blood gas analysis

pH value

7.30

PcvO2

39.8 mmHg

PcvCO2

39.8 mmHg

BE

-7.0 mmol/L

ScvO2

75.5 %

4.vasoactive agent and fluid

Volume of input

0 ml

Volume of output

0 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.5 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

10 mmHg

cardiac output

4.33 L/min

cardiac index

2.66 L/min/m2

stroke volume

61 ml

Stroke Index

37.4 ml/m2

ITBVI

1143 ml/m2

GEDVI

915 ml/m2

EVLWI

10.3 ml/kg

PVPI

1.6

SVRI

2197 DSm2/cm5

CFI

2.6

GEF

15 %

SVV

5 %

PPV

%

dPmax

903

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

mm

mm

mm

mm

3.T6
1..Vital Signs

Temperature

36.7

Heart Rate

69 次/分

Breath

12 次/分

Systolic Pressure

139 mmHg

Diastolic Pressure

67 mmHg

Mean Arterial Pressure

90 mmHg

2..Blood Gas Analysis

Pcv-aCO2

3.9 mmHg

DO2

872.8

VO2

176.2

Ca-vO2

32.4

3.2..、Arterial Blood Gases

PH value

7.35

PaO2

137.2 mmHg

PaCO2

34.7 mmHg

BE

-5.8 mmol/L

SaO2

98.7 %

Blood Lactic Acid Concentration

1.7 mmol/L

Oxygenation index (PaO2/FiO2)

343 mmHg

3.2..、Venous Blood Gas

PH value

7.33

PcvO2

39.9 mmHg

PcvCO2

38.6 mmHg

BE

-6.2 mmol/L

ScvO2

78.9 %

3..Vasoactive Agent and Fluid

Volume of input

1350 ml

Volume of output

470 ml

Volume of urine

450 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

9.6 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

10 mmHg

cardiac output

5.44 L/min

cardiac index

3.34 L/min/m2

stroke volume

78.8 ml

Stroke Index

48.4 ml/m2

ITBVI

1097 ml/m2

GEDVI

878 ml/m2

EVLWI

8.0 ml/kg

PVPI

1.3

SVRI

2036 DSm2/cm5

CFI

3.5

GEF

20 %

SVV

4 %

PPV

%

dPmax

1561

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

mm

mm

mm

mm

4.T12
1..Vital Signs

Temperature

36.5

Heart Rate

76 次/分

Breath

17 次/分

Systolic Pressure

142 mmHg

Diastolic Pressure

70 mmHg

Mean Arterial Pressure

101 mmHg

2..Blood Gas Analysis

Pcv-aCO2

2.8 mmHg

DO2

914.3

VO2

161.4

Ca-vO2

25.9

4.2..、Arterial Blood Gas

PH value

7.39

PaO2

178 mmHg

PaCO2

30.7 mmHg

BE

-9.4 mmol/L

SaO2

99.2 %

Blood Lactic Acid Concentration

1.3 mmol/L

Oxygenation index (PaO2/FiO2)

445 mmHg

4.2..、Venous Blood Gas

PH value

7.38

PcvO2

40.2 mmHg

PcvCO2

33.5 mmHg

BE

-4.9 mmol/L

ScvO2

81.9 %

3..Vasoactive Agent and Fluid

Volume of input

2050 ml

Volume of output

982 ml

Volume of urine

950 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

19.2 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

61.2 mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

12 mmHg

cardiac output

6.23 L/min

cardiac index

3.82 L/min/m2

stroke volume

84.2 ml

Stroke Index

51.6 ml/m2

ITBVI

1129 ml/m2

GEDVI

903 ml/m2

EVLWI

7.8 ml/kg

PVPI

1.3

SVRI

1820 DSm2/cm5

CFI

3.8

GEF

21 %

SVV

3 %

PPV

%

dPmax

1447

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

36.5

Heart Rate

76 次/分

Breath

14 次/分

Systolic Pressure

152 mmHg

Diastolic Pressure

71 mmHg

Mean Arterial Pressure

107 mmHg

2.Blood Gas Analysis

Pcv-aCO2

2.7 mmHg

DO2

929.9

VO2

181.9

Ca-vO2

28.9

5.2.、Arterial Blood Gas

PH value

7.39

PaO2

177 mmHg

PaCO2

28.9 mmHg

BE

-6.7 mmol/L

SaO2

99.2 %

Blood Lactic Acid Concentration

1.2 mmol/L

Oxygenation index (PaO2/FiO2)

442.5 mmHg

5.2.、Venous Blood Gas

PH value

7.36

PcvO2

38.9 mmHg

PcvCO2

31.6 mmHg

BE

-6.8 mmol/L

ScvO2

80 %

3.Vasoactive Agent and Fluid

Volume of input

2777 ml

Volume of output

1593 ml

Volume of urine

1550 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

38.4 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

288 mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

13 mmHg

cardiac output

6.28 L/min

cardiac index

3.85 L/min/m2

stroke volume

82.6 ml

Stroke Index

50.7 ml/m2

ITBVI

1198 ml/m2

GEDVI

959 ml/m2

EVLWI

8.6 ml/kg

PVPI

1.3

SVRI

1951 DSm2/cm5

CFI

3.7

GEF

21 %

SVV

2 %

PPV

%

dPmax

1597

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

37

Heart Rate

72 次/分

Breath

16 次/分

Systolic Pressure

156 mmHg

Diastolic Pressure

72 mmHg

Mean Arterial Pressure

102 mmHg

2.Blood Gas Analysis

Pcv-aCO2

4.6 mmHg

DO2

830.5

VO2

169.6

Ca-vO2

29.0

6.2.、Arterial Blood Gas

PH value

7.41

PaO2

135 mmHg

PaCO2

33.8 mmHg

BE

-1.2 mmol/L

SaO2

96.2 %

Blood Lactic Acid Concentration

1.8 mmol/L

Oxygenation index (PaO2/FiO2)

385.7 mmHg

6.2.、Venous Blood Gas

PH value

7.39

PcvO2

35.8 mmHg

PcvCO2

39.4 mmHg

BE

-1.2 mmol/L

ScvO2

76.7 %

3.Vasoactive Agent and Fluid

Volume of input

5420 ml

Volume of output

4163 ml

Volume of urine

3700 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

38.4 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

432 mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

9 mmHg

cardiac output

5.84 L/min

cardiac index

3.58 L/min/m2

stroke volume

81.1 ml

Stroke Index

49.8 ml/m2

ITBVI

1116 ml/m2

GEDVI

893 ml/m2

EVLWI

8.5 ml/kg

PVPI

1.4

SVRI

2165 DSm2/cm5

CFI

3.7

GEF

20 %

SVV

6 %

PPV

%

dPmax

971

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

36.7

Heart Rate

79 次/分

Breath

16 次/分

Systolic Pressure

145 mmHg

Diastolic Pressure

72 mmHg

Mean Arterial Pressure

99 mmHg

2.Blood Gas Analysis

Pcv-aCO2

6.1 mmHg

DO2

804.8

VO2

131.9

Ca-vO2

23.2

7.2.、Arterial Blood Gas

PH value

7.39

PaO2

92 mmHg

PaCO2

40.9 mmHg

BE

-0.5 mmol/L

SaO2

95.6 %

Blood Lactic Acid Concentration

0.7 mmol/L

Oxygenation index (PaO2/FiO2)

262.9 mmHg

7.2.、Venous Blood Gas

PH value

7.34

PcvO2

39.7 mmHg

PcvCO2

47 mmHg

BE

-0.7 mmol/L

ScvO2

80 %

3.Vasoactive Agent and Fluid

Volume of input

7729 ml

Volume of output

5623 ml

Volume of urine

5550 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

38.4 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

432 mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

8 mmHg

cardiac output

5.7 L/min

cardiac index

3.5 L/min/m2

stroke volume

72.2 ml

Stroke Index

44.3 ml/m2

ITBVI

1049 ml/m2

GEDVI

840 ml/m2

EVLWI

8.2 ml/kg

PVPI

1.4

SVRI

2081 DSm2/cm5

CFI

3.8

GEF

20 %

SVV

11 %

PPV

%

dPmax

939

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

444 pg/ml

cTNI

0.36 ng/ml

Creatine kinase isoenzyme, CKMB

8.2 U/L

2.Renel Function Indices

Creatinine

127 umol/L

Urea nitrogen

11.3 mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

10.3 X10*9/L

neutrophilic granulocyte percentage

91 %

Hb

114 g/L

CRP

299..4 mg/L

Procalcitonin, PCT

7.17 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

6

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

699 pg/ml

cTNI

0.57 ng/ml

Creatine kinase isoenzyme, CKMB

7.3 U/L

2.Renel Function Indices

Creatinine

99 umol/L

Urea nitrogen

8.3 mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

10.2 X10*9/L

neutrophilic granulocyte percentage

91.5 %

Hb

111 g/L

CRP

253.35 mg/L

Procalcitonin, PCT

5.23 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

6

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

316 pg/ml

cTNI

0.43 ng/ml

Creatine kinase isoenzyme, CKMB

6.7 U/L

2.Renel Function Indices

Creatinine

117 umol/L

Urea nitrogen

6.9 mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

8.7 X10*9/L

neutrophilic granulocyte percentage

86.6 %

Hb

110 g/L

CRP

230.4 mg/L

Procalcitonin, PCT

4.15 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

4

11.At the end of the study
4.1.

Transfusion of Red Cells

no

Transfusion of Red Cells

U

Plasma infusion

yes

Plasma infusion

500 ml

platelet transfusion

no

platelet transfusion

U

APACHEⅡ

0

Complication

4.2.prognosis

prognosis

improve

28-day mortality

no

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

duration in ICU

6

duration of mechanical ventilation

96 小时

ICU expenses

47330

Continuous Renal Replacement Therapy

no

Continuous Renal Replacement Therapy

小时