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1..screen
1.1.inclusion standard

aged between 12 and 25

YES

Good general health, no systemic desease

YES

at least 4 upper anterior teeth of which at least 1 tooth had white spot lesion on its buccal surface

YES

Subjects can take a 6-month clinic study and understand test requirements

YES

Subject do not take part in other similar clinical study

YES

1.2.exclusion standard

were Subject is suffering from oral ulcer, ulcerous gingivitis or acute bronchial asthma

NO

Subjects will be or are being treated with fluoride

NO

Subject is from the high fluorine area

NO

Woman who is known to be pregnant or in suckling period over the duration of the study

NO

2..Baseline

gender

Male

Age

15 year

2.1.Soft tissue examination

Perioral area/lips

Normal

Buccal mucosa

Normal

Labial mucosa

Normal

Sublingual mucosa

Normal

Gingiva free/attached

Normal

Tongue

Normal

Palate hard/soft

Normal

Uvula

Normal

Oropharynx

Normal

Other soft/hard tissues

Normal

2.2.QLF index

ΔF

-16.3

white spot area

0.77

ΔQ

-11.85

3..3 month visit
3.1.Soft tissue examination

Soft tissue examination

Normal

3.2.QLF index

ΔF

-12.105

white spot area

0.535

ΔQ

-6.095

4..6 month visit
4.1.Soft tissue examination

Soft tissue examination

Normal

4.2.QLF index

ΔF

-11.405

white spot area

0.355

ΔQ

-4.03