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1.Basic Information
1.1.Basic Information

name

dxc

sex

female

age

60

hospital number

17008489

height

170 cm

weight

70 kg

BSA

1.85 m2

APACHEⅡ

Infection source

abdominal

date

2017/3/17 年/月/日

Sequential Organ Failure Assessment

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

no

no

no

no

no

2.T0
1.

yes

头孢哌酮舒巴坦2.0ivgtt q8h、泰能0.5ivgtt q6h

vasoactive agent

norepinephrine
/
vasopressin

4140 min

0 min

4140 min

2.vital signs

Temperature

37

Heart Rate

113 次/分

Breath

15 次/分

Systolic pressure (SP)

131 mmHg

Diastolic pressure

46 mmHg

mean arterial pressure

63 mmHg

3.Blood Gas Analysis

Pcv-aCO2

-2 mmHg

DO2

971.66

VO2

229.52

Ca-vO2

25.82

2.3.、arterial blood gas analysis

pH value

7.29

PaO2

56 mmHg

PaCO2

44 mmHg

BE

-5.7 mmol/L(±2.3mmol/L)

SaO2

91.3 %

Blood lactic acid concentration, LAC

11.2 mmol/L

Oxygenation index (PaO2/FiO2)

93.33 mmHg

2.3.、Central venous blood gas analysis

pH value

7.31

PcvO2

36 mmHg

PcvCO2

42 mmHg

BE

-5.3 mmol/L

ScvO2

69.7 %

4.vasoactive agent and fluid

Volume of input

100 ml

Volume of output

150 ml

Volume of urine

0 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.8 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

Pituitrin

5.PiCCO parameters

CVP

3 mmHg

cardiac output

8.91 L/min

cardiac index

4.65 L/min/m2

stroke volume

85 ml

Stroke Index

33 ml/m2

ITBVI

785 ml/m2

GEDVI

628 ml/m2

EVLWI

7 ml/kg

PVPI

1.6

SVRI

939 DSm2/cm5

CFI

8

GEF

30 %

SVV

13 %

PPV

11 %

dPmax

1032

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

2

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

22.9 mm

IVC(expiratory phase)

18.6 mm

respiratory variations of inferior vena cavae diameter

20.72 %

2.8.2.、

mm

mm

mm

mm

3.T6
1..Vital Signs

Temperature

34.5

Heart Rate

79 次/分

Breath

19 次/分

Systolic Pressure

114 mmHg

Diastolic Pressure

56 mmHg

Mean Arterial Pressure

61 mmHg

2..Blood Gas Analysis

Pcv-aCO2

7 mmHg

DO2

981.45

VO2

261.11

Ca-vO2

29.44

3.2..、Arterial Blood Gases

PH value

7.34

PaO2

66 mmHg

PaCO2

37 mmHg

BE

-1.5 mmol/L

SaO2

92.3 %

Blood Lactic Acid Concentration

8.1 mmol/L

Oxygenation index (PaO2/FiO2)

110 mmHg

3.2..、Venous Blood Gas

PH value

7.36

PcvO2

32 mmHg

PcvCO2

44 mmHg

BE

-1.3 mmol/L

ScvO2

67.7 %

3..Vasoactive Agent and Fluid

Volume of input

1500 ml

Volume of output

1100 ml

Volume of urine

80 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

5.12 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

4.32 U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

14 mmHg

cardiac output

8.9 L/min

cardiac index

4.64 L/min/m2

stroke volume

117 ml

Stroke Index

61 ml/m2

ITBVI

978 ml/m2

GEDVI

782 ml/m2

EVLWI

9 ml/kg

PVPI

1.7

SVRI

939 DSm2/cm5

CFI

6.4

GEF

61 %

SVV

15 %

PPV

8 %

dPmax

2886

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

3

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

19.8 mm

IVC(expiratory phase)

18.2 mm

Respiratory variations of inferior vena cavae diameter

8.42 %

3.7..2、

mm

mm

mm

mm

4.T12
1..Vital Signs

Temperature

35

Heart Rate

82 次/分

Breath

19 次/分

Systolic Pressure

134 mmHg

Diastolic Pressure

50 mmHg

Mean Arterial Pressure

76 mmHg

2..Blood Gas Analysis

Pcv-aCO2

-2.00 mmHg

DO2

967.79

VO2

278.00

Ca-vO2

31.24

4.2..、Arterial Blood Gas

PH value

7.39

PaO2

67 mmHg

PaCO2

38 mmHg

BE

-1.7 mmol/L

SaO2

90.00 %

Blood Lactic Acid Concentration

8.2 mmol/L

Oxygenation index (PaO2/FiO2)

111.67 mmHg

4.2..、Venous Blood Gas

PH value

7.4

PcvO2

64 mmHg

PcvCO2

36 mmHg

BE

-2.5 mmol/L

ScvO2

64.10 %

3..Vasoactive Agent and Fluid

Volume of input

4416 ml

Volume of output

2913 ml

Volume of urine

110 ml

Ultrafiltration Volume

1200 ml

Norepinephrine Dosage

28 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

8.64 U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

13 mmHg

cardiac output

8.9 L/min

cardiac index

4.64 L/min/m2

stroke volume

117 ml

Stroke Index

61 ml/m2

ITBVI

978 ml/m2

GEDVI

782 ml/m2

EVLWI

9 ml/kg

PVPI

1.7

SVRI

939 DSm2/cm5

CFI

6.4

GEF

31 %

SVV

15 %

PPV

8 %

dPmax

2886

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

3

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

2.12 mm

IVC(expiratory phase)

1.88 mm

Respiratory variations of inferior vena cavae diameter

12 %

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

35.2

Heart Rate

83 次/分

Breath

15 次/分

Systolic Pressure

127 mmHg

Diastolic Pressure

36 mmHg

Mean Arterial Pressure

58 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.00 mmHg

DO2

864.32

VO2

317.22

Ca-vO2

43.43

5.2.、Arterial Blood Gas

PH value

7.38

PaO2

84 mmHg

PaCO2

41 mmHg

BE

-1.3 mmol/L

SaO2

97.70 %

Blood Lactic Acid Concentration

7.2 mmol/L

Oxygenation index (PaO2/FiO2)

140.00 mmHg

5.2.、Venous Blood Gas

PH value

7.36

PcvO2

32 mmHg

PcvCO2

44 mmHg

BE

-1.3 mmol/L

ScvO2

61.00 %

3.Vasoactive Agent and Fluid

Volume of input

6319 ml

Volume of output

5893 ml

Volume of urine

110 ml

Ultrafiltration Volume

1950 ml

Norepinephrine Dosage

133.42 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

17.28 U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

11 mmHg

cardiac output

7.33 L/min

cardiac index

3.83 L/min/m2

stroke volume

114 ml

Stroke Index

59 ml/m2

ITBVI

747 ml/m2

GEDVI

598 ml/m2

EVLWI

7 ml/kg

PVPI

1.8

SVRI

881 DSm2/cm5

CFI

6.9

GEF

34 %

SVV

15 %

PPV

7 %

dPmax

3187

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

2.31 mm

IVC(expiratory phase)

2.03 mm

Respiratory variations of inferior vena cavae diameter

12.90 %

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

36.6

Heart Rate

75 次/分

Breath

25 次/分

Systolic Pressure

133 mmHg

Diastolic Pressure

52 mmHg

Mean Arterial Pressure

78 mmHg

2.Blood Gas Analysis

Pcv-aCO2

4 mmHg

DO2

879.63

VO2

270.50

Ca-vO2

34.41

6.2.、Arterial Blood Gas

PH value

7.52

PaO2

69 mmHg

PaCO2

31 mmHg

BE

1.7 mmol/L

SaO2

97.7 %

Blood Lactic Acid Concentration

6.5 mmol/L

Oxygenation index (PaO2/FiO2)

115.00 mmHg

6.2.、Venous Blood Gas

PH value

7.49

PcvO2

28 mmHg

PcvCO2

35 mmHg

BE

2.4 mmol/L

ScvO2

67.60 %

3.Vasoactive Agent and Fluid

Volume of input

10200 ml

Volume of output

11162 ml

Volume of urine

124 ml

Ultrafiltration Volume

7695 ml

Norepinephrine Dosage

273.02 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

34.56 U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

14 mmHg

cardiac output

7.89 L/min

cardiac index

4.12 L/min/m2

stroke volume

122 ml

Stroke Index

63 ml/m2

ITBVI

1019 ml/m2

GEDVI

875 ml/m2

EVLWI

9 ml/kg

PVPI

1.6

SVRI

1705 DSm2/cm5

CFI

5.5

GEF

40 %

SVV

13 %

PPV

11 %

dPmax

2187

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

4

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

25.4 mm

IVC(expiratory phase)

22.9 mm

Respiratory variations of inferior vena cavae diameter

10.35 %

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

37.3

Heart Rate

97 次/分

Breath

12 次/分

Systolic Pressure

139 mmHg

Diastolic Pressure

65 mmHg

Mean Arterial Pressure

90 mmHg

2.Blood Gas Analysis

Pcv-aCO2

6 mmHg

DO2

698.06

VO2

202.46

Ca-vO2

30.59

7.2.、Arterial Blood Gas

PH value

7.48

PaO2

79 mmHg

PaCO2

34 mmHg

BE

1.1 mmol/L

SaO2

97.70 %

Blood Lactic Acid Concentration

5.8 mmol/L

Oxygenation index (PaO2/FiO2)

131.67 mmHg

7.2.、Venous Blood Gas

PH value

7.46

PcvO2

31 mmHg

PcvCO2

40 mmHg

BE

3 mmol/L

ScvO2

69.30 %

3.Vasoactive Agent and Fluid

Volume of input

14421 ml

Volume of output

16570 ml

Volume of urine

182 ml

Ultrafiltration Volume

8095 ml

Norepinephrine Dosage

320.52 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

51.84 U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

14 mmHg

cardiac output

6.65 L/min

cardiac index

3.47 L/min/m2

stroke volume

7 ml

Stroke Index

51 ml/m2

ITBVI

837 ml/m2

GEDVI

669 ml/m2

EVLWI

6 ml/kg

PVPI

1.3

SVRI

1820 DSm2/cm5

CFI

5.6

GEF

34.00 %

SVV

6.00 %

PPV

5 %

dPmax

1378

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

4

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

24.6 mm

Respiratory variations of inferior vena cavae diameter

21.2 %

IVC(inspiratory phase)

14.85 mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

1230 pg/ml

cTNI

0.318 ng/ml

Creatine kinase isoenzyme, CKMB

43.7 U/L

2.Renel Function Indices

Creatinine

163 umol/L

Urea nitrogen

7.4 mmol/l

MDRD

37.62 ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

21.1 X10*9/L

neutrophilic granulocyte percentage

87.8 %

Hb

g/L

CRP

19.3 mg/L

Procalcitonin, PCT

2.1 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

20

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

1240 pg/ml

cTNI

0.455 ng/ml

Creatine kinase isoenzyme, CKMB

46.6 U/L

2.Renel Function Indices

Creatinine

134 umol/L

Urea nitrogen

5 mmol/l

MDRD

47.163 ml/min/1.73m2

3.Blood Routine Tests

WBC

22.2 X10*9/L

neutrophilic granulocyte percentage

96.1 %

Hb

g/L

CRP

57.2 mg/L

Procalcitonin, PCT

3.05 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

20

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

984 pg/ml

cTNI

0.829 ng/ml

Creatine kinase isoenzyme, CKMB

34.5 U/L

2.Renel Function Indices

Creatinine

76 umol/L

Urea nitrogen

5.4 mmol/L

MDRD

90.745 ml/min/1.73m2

3.Blood Routine Tests

WBC

15.3 X10*9/L

neutrophilic granulocyte percentage

85.7 %

Hb

g/L

CRP

56.7 mg/L

Procalcitonin, PCT

2.02 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

20

11.At the end of the study
4.1.

Transfusion of Red Cells

yes

Transfusion of Red Cells

3 U

Plasma infusion

yes

Plasma infusion

1500 ml

platelet transfusion

yes

platelet transfusion

10 U

APACHEⅡ

21

Complication

no

4.2.prognosis

prognosis

die

28-day mortality

yes

survival time(day)

7

death time

2017/3/21 yyyy/mm/dd

diagnosis of death

感染性休克、腹腔闭合性损伤、失血性休克

length of stay

7

duration in ICU

7

duration of mechanical ventilation

168 小时

ICU expenses

166984.22

Continuous Renal Replacement Therapy

yes

Continuous Renal Replacement Therapy

120 小时