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1.Basic Information
1.1.Basic Information

name

hye

sex

female

age

66

hospital number

17012261

height

155 cm

weight

48 kg

BSA

1.4 m2

APACHEⅡ

11

Infection source

abdominal

date

2017/4/30 年/月/日

Sequential Organ Failure Assessment

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

trachea cannula

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

no

no

no

no

no

2.T0
1.

yes

泰能、万古霉素

vasoactive agent

norepinephrine

10 min

10 min

20 min

2.vital signs

Temperature

36.7

Heart Rate

95 次/分

Breath

22 次/分

Systolic pressure (SP)

141 mmHg

Diastolic pressure

67 mmHg

mean arterial pressure

88 mmHg

3.Blood Gas Analysis

Pcv-aCO2

3 mmHg

DO2

580.27

VO2

144.88

Ca-vO2

20.65

2.3.、arterial blood gas analysis

pH value

7.38

PaO2

116 mmHg

PaCO2

37 mmHg

BE

-3.5 mmol/L(±2.3mmol/L)

SaO2

99.70 %

Blood lactic acid concentration, LAC

1.4 mmol/L

Oxygenation index (PaO2/FiO2)

290.00 mmHg

2.3.、Central venous blood gas analysis

pH value

7.36

PcvO2

43 mmHg

PcvCO2

40 mmHg

BE

-3.1 mmol/L

ScvO2

74.70 %

4.vasoactive agent and fluid

Volume of input

600 ml

Volume of output

150 ml

Volume of urine

150 ml

ultrafiltration volume

0 ml

norepinephrine

yes

Norepinephrine Dosage

0.0023 μg/Kg/min

dopamine

no

Dopamine Dosage

μg/Kg/min

Dobutamine

No

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

7 mmHg

cardiac output

7.09 L/min

cardiac index

5.06 L/min/m2

stroke volume

85 ml

Stroke Index

60 ml/m2

ITBVI

1073 ml/m2

GEDVI

859 ml/m2

EVLWI

6 ml/kg

PVPI

0.9

SVRI

800 DSm2/cm5

CFI

5.7

GEF

23.00 %

SVV

7.00 %

PPV

5 %

dPmax

1514

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

2

LUS

4

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

20.7 mm

IVC(expiratory phase)

19.4 mm

respiratory variations of inferior vena cavae diameter

6.48 %

2.8.2.、

mm

mm

mm

mm

3.T6
1..Vital Signs

Temperature

37.3

Heart Rate

100 次/分

Breath

15 次/分

Systolic Pressure

99 mmHg

Diastolic Pressure

48 mmHg

Mean Arterial Pressure

66 mmHg

2..Blood Gas Analysis

Pcv-aCO2

5 mmHg

DO2

783.77

VO2

168.21

Ca-vO2

21.56

3.2..、Arterial Blood Gases

PH value

7.39

PaO2

125 mmHg

PaCO2

35 mmHg

BE

-4 mmol/L

SaO2

99.80 %

Blood Lactic Acid Concentration

2.2 mmol/L

Oxygenation index (PaO2/FiO2)

312.50 mmHg

3.2..、Venous Blood Gas

PH value

7.36

PcvO2

46 mmHg

PcvCO2

40 mmHg

BE

-3.4 mmol/L

ScvO2

78.30 %

3..Vasoactive Agent and Fluid

Volume of input

1600 ml

Volume of output

1500 ml

Volume of urine

1500 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

1.56 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

7 mmHg

cardiac output

7.89 L/min

cardiac index

5.62 L/min/m2

stroke volume

73 ml

Stroke Index

52 ml/m2

ITBVI

938 ml/m2

GEDVI

751 ml/m2

EVLWI

7 ml/kg

PVPI

1.2

SVRI

982 DSm2/cm5

CFI

7.3

GEF

26.00 %

SVV

7.00 %

PPV

6 %

dPmax

1448

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

2

LUS

4

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

21.3 mm

IVC(expiratory phase)

19.5 mm

Respiratory variations of inferior vena cavae diameter

8.82 %

3.7..2、

mm

mm

mm

mm

4.T12
1..Vital Signs

Temperature

38.6

Heart Rate

101 次/分

Breath

15 次/分

Systolic Pressure

133 mmHg

Diastolic Pressure

61 mmHg

Mean Arterial Pressure

92 mmHg

2..Blood Gas Analysis

Pcv-aCO2

3 mmHg

DO2

519.42

VO2

115.30

Ca-vO2

17.02

4.2..、Arterial Blood Gas

PH value

7.38

PaO2

141 mmHg

PaCO2

34 mmHg

BE

-4.8 mmol/L

SaO2

99.90 %

Blood Lactic Acid Concentration

2.7 mmol/L

Oxygenation index (PaO2/FiO2)

352.50 mmHg

4.2..、Venous Blood Gas

PH value

7.39

PcvO2

46 mmHg

PcvCO2

37 mmHg

BE

-2.5 mmol/L

ScvO2

77.60 %

3..Vasoactive Agent and Fluid

Volume of input

3400 ml

Volume of output

1100 ml

Volume of urine

450 ml

Ultrafiltration Volume

0 ml

Norepinephrine Dosage

3.2 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4..PiCCO Parameters

CVP

7 mmHg

cardiac output

6.89 L/min

cardiac index

4.07 L/min/m2

stroke volume

76 ml

Stroke Index

59 ml/m2

ITBVI

1035 ml/m2

GEDVI

829 ml/m2

EVLWI

7 ml/kg

PVPI

1

SVRI

1459 DSm2/cm5

CFI

4.8

GEF

21.00 %

SVV

8.00 %

PPV

5 %

dPmax

907

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

2

LUS

4

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

20.7 mm

IVC(expiratory phase)

19.8 mm

Respiratory variations of inferior vena cavae diameter

4.44 %

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

35.7

Heart Rate

76 次/分

Breath

14 次/分

Systolic Pressure

111 mmHg

Diastolic Pressure

61 mmHg

Mean Arterial Pressure

84 mmHg

2.Blood Gas Analysis

Pcv-aCO2

5.00 mmHg

DO2

611.49

VO2

211.24

Ca-vO2

32.87

5.2.、Arterial Blood Gas

PH value

7.49

PaO2

140 mmHg

PaCO2

34 mmHg

BE

1.6 mmol/L

SaO2

100.00 %

Blood Lactic Acid Concentration

1.4 mmol/L

Oxygenation index (PaO2/FiO2)

350.00 mmHg

5.2.、Venous Blood Gas

PH value

7.47

PcvO2

33 mmHg

PcvCO2

39 mmHg

BE

3.4 mmol/L

ScvO2

65.30 %

3.Vasoactive Agent and Fluid

Volume of input

7280 ml

Volume of output

4600 ml

Volume of urine

1200 ml

Ultrafiltration Volume

1300 ml

Norepinephrine Dosage

6 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

7 mmHg

cardiac output

6.41 L/min

cardiac index

4.57 L/min/m2

stroke volume

68 ml

Stroke Index

49 ml/m2

ITBVI

892 ml/m2

GEDVI

714 ml/m2

EVLWI

6 ml/kg

PVPI

1

SVRI

1262 DSm2/cm5

CFI

6.2

GEF

26.00 %

SVV

4.00 %

PPV

4 %

dPmax

886

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

2

LUS

4

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

20.3 mm

IVC(expiratory phase)

19.7 mm

Respiratory variations of inferior vena cavae diameter

3.0 %

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

36.3

Heart Rate

79 次/分

Breath

12 次/分

Systolic Pressure

118 mmHg

Diastolic Pressure

72 mmHg

Mean Arterial Pressure

87 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.00 mmHg

DO2

636.14

VO2

130.24

Ca-vO2

20.88

6.2.、Arterial Blood Gas

PH value

7.44

PaO2

119 mmHg

PaCO2

41 mmHg

BE

3.2 mmol/L

SaO2

98.80 %

Blood Lactic Acid Concentration

1.8 mmol/L

Oxygenation index (PaO2/FiO2)

297.50 mmHg

6.2.、Venous Blood Gas

PH value

7.43

PcvO2

50 mmHg

PcvCO2

44 mmHg

BE

3.7 mmol/L

ScvO2

78.50 %

3.Vasoactive Agent and Fluid

Volume of input

10252 ml

Volume of output

7545 ml

Volume of urine

1660 ml

Ultrafiltration Volume

2265 ml

Norepinephrine Dosage

6 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

7 mmHg

cardiac output

6.3 L/min

cardiac index

5.03 L/min/m2

stroke volume

78 ml

Stroke Index

56 ml/m2

ITBVI

966 ml/m2

GEDVI

772 ml/m2

EVLWI

6 ml/kg

PVPI

1

SVRI

2088 DSm2/cm5

CFI

6.4

GEF

27.00 %

SVV

6.00 %

PPV

8 %

dPmax

1251

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

2

LUS

4

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

20.2 mm

IVC(expiratory phase)

20 mm

Respiratory variations of inferior vena cavae diameter

1.00 %

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

36.2

Heart Rate

79 次/分

Breath

15 次/分

Systolic Pressure

124 mmHg

Diastolic Pressure

68 mmHg

Mean Arterial Pressure

87 mmHg

2.Blood Gas Analysis

Pcv-aCO2

3.00 mmHg

DO2

659.54

VO2

136.50

Ca-vO2

21.04

7.2.、Arterial Blood Gas

PH value

7.64

PaO2

78 mmHg

PaCO2

20 mmHg

BE

2.5 mmol/L

SaO2

94.00 %

Blood Lactic Acid Concentration

2.2 mmol/L

Oxygenation index (PaO2/FiO2)

195.00 mmHg

7.2.、Venous Blood Gas

PH value

7.58

PcvO2

34 mmHg

PcvCO2

23 mmHg

BE

-0.2 mmol/L

ScvO2

74.50 %

3.Vasoactive Agent and Fluid

Volume of input

13352 ml

Volume of output

9695 ml

Volume of urine

1210 ml

Ultrafiltration Volume

2265 ml

Norepinephrine Dosage

6 mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

no

4.PiCCO Parameters

CVP

7 mmHg

cardiac output

6.53 L/min

cardiac index

3.72 L/min/m2

stroke volume

65 ml

Stroke Index

43 ml/m2

ITBVI

970 ml/m2

GEDVI

776 ml/m2

EVLWI

7 ml/kg

PVPI

1.2

SVRI

1529 DSm2/cm5

CFI

4.7

GEF

25.00 %

SVV

10.00 %

PPV

8 %

dPmax

1121

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

2

LUS

4

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

20.3 mm

Respiratory variations of inferior vena cavae diameter

20.1 %

IVC(inspiratory phase)

0.99 mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

594 pg/ml

cTNI

0.099 ng/ml

Creatine kinase isoenzyme, CKMB

21.6 U/L

2.Renel Function Indices

Creatinine

131 umol/L

Urea nitrogen

11.4 mmol/l

MDRD

35.233 ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

4.2 X10*9/L

neutrophilic granulocyte percentage

91.8 %

Hb

g/L

CRP

76.5 mg/L

Procalcitonin, PCT

1.45 ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

26

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

543 pg/ml

cTNI

0.076 ng/ml

Creatine kinase isoenzyme, CKMB

23.6 U/L

2.Renel Function Indices

Creatinine

80 umol/L

Urea nitrogen

6.4 mmol/l

MDRD

62.246 ml/min/1.73m2

3.Blood Routine Tests

WBC

5.2 X10*9/L

neutrophilic granulocyte percentage

91 %

Hb

g/L

CRP

91.5 mg/L

Procalcitonin, PCT

0.927 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

22

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

692 pg/ml

cTNI

0.074 ng/ml

Creatine kinase isoenzyme, CKMB

25.8 U/L

2.Renel Function Indices

Creatinine

124 umol/L

Urea nitrogen

8.2 mmol/L

MDRD

37.538 ml/min/1.73m2

3.Blood Routine Tests

WBC

4.1 X10*9/L

neutrophilic granulocyte percentage

77.5 %

Hb

g/L

CRP

33.9 mg/L

Procalcitonin, PCT

0.771 ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

15

11.At the end of the study
4.1.

Transfusion of Red Cells

yes

Transfusion of Red Cells

8.5 U

Plasma infusion

yes

Plasma infusion

750 ml

platelet transfusion

yes

platelet transfusion

10 U

APACHEⅡ

21

Complication

no

4.2.prognosis

prognosis

improve

28-day mortality

no

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

56

duration in ICU

25

duration of mechanical ventilation

25 小时

ICU expenses

Continuous Renal Replacement Therapy

yes

Continuous Renal Replacement Therapy

72 小时