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1.Basic Information
1.1.Basic Information

name

syc

sex

female

age

84

hospital number

17022181

height

158 cm

weight

50 kg

BSA

1.51 m2

APACHEⅡ

20

Infection source

nervous system

date

2017/7/3 年/月/日

Sequential Organ Failure Assessment

Fluid resuscitation

CVP8-12 mmHg
/
MAP≥65 mmHg
/
ScvO2≥70%
/
urine volume≥0.5

1.2.Inclusion Criteria

age>=60

yes

septic shock

yes

mechanical ventilation

Early fluid resuscitation

yes

1.3.Exclusion Criteria

age<60

no

Pregnant woman

no

advanced malignant tumor

no

Pulmonary interstitial fibrosis

no

Serious arrhythmia

no

Small Tidal Volume Ventilation

no

Liver failure

no

Refuse to participate

no

1.4.Past medical history

Heart disease

no

yes

no

no

no

no

2.T0
1.

vasoactive agent

min

min

min

2.vital signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic pressure (SP)

mmHg

Diastolic pressure

mmHg

mean arterial pressure

mmHg

3.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

2.3.、arterial blood gas analysis

pH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L(±2.3mmol/L)

SaO2

%

Blood lactic acid concentration, LAC

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

2.3.、Central venous blood gas analysis

pH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

4.vasoactive agent and fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

ultrafiltration volume

ml

norepinephrine

Norepinephrine Dosage

μg/Kg/min

dopamine

Dopamine Dosage

μg/Kg/min

Dobutamine

Dobutamine Dosage

μg/Kg/min

5.PiCCO parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

6.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

7.lung ultrasound

the number of B line

LUS

B+ Zone

8.inferior vena cava
2.8.1.、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

respiratory variations of inferior vena cavae diameter

%

2.8.2.、

mm

mm

mm

mm

3.T6
1..Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2..Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

3.2..、Arterial Blood Gases

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

3.2..、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3..Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
3.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

3.7..2、

mm

mm

mm

mm

4.T12
1..Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2..Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

4.2..、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

4.2..、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3..Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4..PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5..Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6..Lung Ultrasound

The number of B line

LUS

B+ Zone

7..Inferior Vena Cava
4.7..1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

4.7..2、

mm

mm

mm

mm

5.T24
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

5.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

5.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
5.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

5.7.2、

mm

mm

mm

mm

6.T48
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

6.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

6.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
6.7.1、

IVC(inspiratory phase)

mm

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

6.7.2、

mm

mm

mm

mm

7.T72
1.Vital Signs

Temperature

Heart Rate

次/分

Breath

次/分

Systolic Pressure

mmHg

Diastolic Pressure

mmHg

Mean Arterial Pressure

mmHg

2.Blood Gas Analysis

Pcv-aCO2

mmHg

DO2

VO2

Ca-vO2

7.2.、Arterial Blood Gas

PH value

PaO2

mmHg

PaCO2

mmHg

BE

mmol/L

SaO2

%

Blood Lactic Acid Concentration

mmol/L

Oxygenation index (PaO2/FiO2)

mmHg

7.2.、Venous Blood Gas

PH value

PcvO2

mmHg

PcvCO2

mmHg

BE

mmol/L

ScvO2

%

3.Vasoactive Agent and Fluid

Volume of input

ml

Volume of output

ml

Volume of urine

ml

Ultrafiltration Volume

ml

Norepinephrine Dosage

mg

Dopamine Dosage

mg

Epinephrine Dosage

mg

Pituitrin Dosage

U

Dobutamine Dosage

mg

Milrinone Dosage

mg

Levosimendan

4.PiCCO Parameters

CVP

mmHg

cardiac output

L/min

cardiac index

L/min/m2

stroke volume

ml

Stroke Index

ml/m2

ITBVI

ml/m2

GEDVI

ml/m2

EVLWI

ml/kg

PVPI

SVRI

DSm2/cm5

CFI

GEF

%

SVV

%

PPV

%

dPmax

5.Cardiac Ultrasound

LVEF

%

FS

%

SV

ml

CO

L/min

E peak

A peak

E/A

Ea(ventricular septum)

Ea(lateral wall)

E/Ea(ventricular septum)

E/Ea(lateral wall)

MAPSE

mm

TAPSE

mm

RV size

LVEDV

ml

LVEDD

cm

6.Lung Ultrasound

The number of B line

LUS

B+ Zone

7.Inferior Vena Cava
7.7.1、

IVC(expiratory phase)

mm

Respiratory variations of inferior vena cavae diameter

%

IVC(inspiratory phase)

mm

7.7.2、

mm

mm

mm

mm

8.Day 1
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/l

MDRD

ml/min/1.73m2

Date of examination

yyyy-mm-dd

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

Date of test

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

9.Day 2
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/l

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

10.Day 3
1.Cardiac Function Indices

NT-proBNP

pg/ml

BNP

pg/ml

cTNI

ng/ml

Creatine kinase isoenzyme, CKMB

U/L

2.Renel Function Indices

Creatinine

umol/L

Urea nitrogen

mmol/L

MDRD

ml/min/1.73m2

3.Blood Routine Tests

WBC

X10*9/L

neutrophilic granulocyte percentage

%

Hb

g/L

CRP

mg/L

Procalcitonin, PCT

ng/ml

4.Sequential Organ Failure Assessment

Sequential Organ Failure Assessment

11.At the end of the study
4.1.

Transfusion of Red Cells

Transfusion of Red Cells

U

Plasma infusion

Plasma infusion

ml

platelet transfusion

platelet transfusion

U

APACHEⅡ

Complication

4.2.prognosis

prognosis

28-day mortality

survival time(day)

death time

yyyy/mm/dd

diagnosis of death

length of stay

duration in ICU

duration of mechanical ventilation

小时

ICU expenses

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

小时