1.Screening
1.1.Management for Progress
1.2.inception criteria
1.3.Exclusion Criteria
2.Baseline
2.1.Management of the progress
2.2.General information
2.4.Blood Routine Tests
2.8.Serum Liver Function Tests
3.operative date
6.Follow-up 2
7.Follow-up 3
8.Management system of participants
9.Speciman management system
14.3.Specimen collection SOP
10.Data management system
11.ADR/ADE management system