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1.Screening
1.1.Management for Progress
1.2.Inclusion Criteria

absence of PAH or mild PAH

yes

Echocardiography within 24 hours of birth

performed

Surgical approach

Thoracoscopic repair

Location of diaphragmatic hernia

left side

lung-to-head ratio

LHR>1.0

Prenatal testing tool

Tertiary obstetric ultrasound

Prenatal examination time

gestation was at 24 to 28 weeks

The operative department

Department of pediatric thoracic surgery

congenital diaphragmatic hernia

yes

neonates

yes

Place of birth

Born in the obstetrics department of our hospital

Birthdate

Born between September 5, 2017 and May 9, 2019

1.3.Exclusion Criteria

giving up surgical treatment because of failure in meeting the specified physiological indicators before surgery

yes

arrhythmia

yes

diagnosed with other heart malformations than incomplete closure of patent ductus arteriosus (PDA) and patent foramen ovale (PFO)

yes

echocardiography indicating moderate to severe PAH 24 h after delivery

yes

laparoscopic diaphragmatic hernia repair

yes

right-sided or bilateral diaphragmatic hernia

yes

not neonates

yes

Transferred to our hospital after delivery from another hospital

yes

lung-to-head ratio

LHR≤1.0

2.Baseline
2.1.Management of the progress
2.2.General information

age when receiving surgery (duration of preoperative mechanical ventilation)

59 h

birth weight

2.95 kg

male or female

male

natural labor or C-section

natural labor

days of pregnancy

279 day

LHR-based mild or moderate CDH

mild

2.3.Physical examination

Apgar score at 1 minute after birth

8

2.4.Blood Routine Tests
2.5.Urine and Stool Routine Tests
2.6.Blood Electrolytes Tests
2.7.Coagulation Function Tests
2.8.Serum Liver Function Tests
2.9.HBV Markers Test
2.10.Renel Function Test
2.11.Heat Function Examination

preoperative PAH-free or mild PAH

PAH-free

2.12.Blood Cell Morphology
2.13.Image Examinations

value of LHR

2.6

2.14.Nervous System Examination
2.15.Lung Function Examination
2.16.Blood Gas Analysis
2.17.Physical Ability Examination
2.18.Health Relative Quality of Life
3.In the process of the treatment
3.1.Treatment Record

postoperative mortality

not

incidence of postoperative GERD (gastric acid retention)

not

incidence of postoperative moderate-to-severe PAH

not

duration of fasting

193 hour

duration of using antibiotics

274 hour

incision infection

not

postoperative pulmonary infection

not

duration of postoperative drainage

2 day

postoperative drainage volume

30 ml

duration of postoperative mechanical ventilation

132 hour

hernia sac-free or hernia sac

hernia sac-free

operation duration

106 minute

4.At the end of the treatment
4.1.Management for Progress

hospitalization costs

41678 yuan

hospital stay

13 day

4.2.Physical examination
4.3.Blood Routine Tests
4.4.Urine and Stool Routine Tests
4.5.Serum Electrolytes Tests
4.6.Liver Function Tests
4.7.HBV Markers Test
4.8.Renel Function Test
4.9.Heat Function Examination
4.10.Image Examinations
4.11.Blood Cell Morphology
4.12.Nervous System Examination
4.13.Lung Function Examination
4.14.Blood Gas Analysis
4.15.Physical Sbility Examination
4.16.Health Relative Quality of Life
5.Follow-up 1
1.Blood routine test
6.Follow-up 2

recurrence during follow-ups

yes
/
not

7.Follow-up 3
8.Management system of participants
9.Speciman management system
10.Data management system
11.ADR/ADE management system
12.Madicine management system
13.Instruments management system
14.SOPs
14.1.Treatment SOP
14.2.Nursing SOP
14.3.Specimen collection SOP
15.Research team
15.1.Institutions
15.2.Researchers
16.Design, Methods
16.1.Calculation of sample size