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1.Screening
1.1.Inclusion Criteria

Chronic low back pain is accompanied by more than two clinical manifestations

Skeletally mature patients with chronic (>=6 months) isolated lumbar back pain, who had not responded to at least 6 months of nonoperative management

MRI evidence of intervertebral disc degeneration

Complete medical record

Volunteer to participate in the trial, and signed the informed consent

1.2.Exclusion Criteria

Previous lumbar spine surgery

With at least one disease as listed following

With at least one disease as listed following

Pregnant and lactating women

Liver and kidney dysfunction

With at least one disease as listed following

Meet at least one condition as listed following

The researchers did not think it would be appropriate to participate in this clinical trial.

2.Baseline
2.1.General information

General information

2.2.Physical examination

Physical examination

2.3.Blood Routine Tests

Blood Routine Tests

2.4.Urine and Stool Routine Tests

Urine and Stool Routine Tests

2.5.Blood Electrolytes Tests

Blood Electrolytes Tests

2.6.Coagulation Function Tests

Coagulation Function Tests

2.7.Serum Liver Function Tests

Serum Liver Function Tests

2.8.HBV Markers Test

HBV Markers Test

2.9.Renel Function Test

Renel Function Test

2.10.Heat Function Examination

Heat Function Examination

2.11.Blood Cell Morphology

Blood Cell Morphology

2.12.Image Examinations

Image Examinations

2.13.Nervous System Examination

Nervous System Examination

2.14.Lung Function Examination

Lung Function Examination

2.15.Health Relative Quality of Life

Health Relative Quality of Life

3.In the process of the treatment
3.1.Treatment Record

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

4.At the end of the treatment
4.1.Efficacy evaluation

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

4.2.Physical examination

Physical examination

4.3.Nervous System Examination

Nervous System Examination

4.4.Health Relative Quality of Life

Health Relative Quality of Life

5.Follow-up 1

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

6.Follow-up 2

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

VAS scoring (visual analogue scoring system)

The Oswestry Disability Index

%

7.Follow-up 3

VAS scoring (visual analogue scoring system)

VAS scoring (visual analogue scoring system)

VAS scoring (visual analogue scoring system)

VAS scoring (visual analogue scoring system)

8.Data management system

Data management system

9.ADR/ADE management system

ADR/ADE management system

10.Madicine management system

Madicine management system

11.Instruments management system

Instruments management system

12.Research team
12.1.Institutions

Institutions

12.2.Researchers

Researchers

13.Design, Methods
13.1.Calculation of sample size

Calculation of sample size

14.Treatment SOP
15.Nursing SOP