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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:10;胃肠问题:30;呼吸:20;雷诺:20;溃疡:0;总体影响:50

digital ulcer burden

0

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

未婚

Monthly per capita household income

5000 RMB

weight

46 kg

height

160 cm

gender

age

27

nation

place of residence

深圳

occupation

公司职员

degree of education

大学

2.3.Physical examination

physical examination and take photos

physical examination

normal

2.4.Blood Routine Tests

normal

2.5.urine routine test

normal

negative

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

正常

2.7.Renel Function Test

renal function

正常

2.8.Image Examinations

Lung CT

ILD

pulmonary CT

ILD

2.13.SSA

SSA

8

2.14.MRSS

MRSS

8

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

19

3.In the process of the treatment

other drugs

硝苯地平

3.1.Treatment Record

medicine

tofacitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

digital ulcer burden

0

physical examination

正常

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

renal function test

正常

other blood tests

未见异常

4.10.Image Examinations

Lung CT

ILD

4.13.Lung Function Examination

St.George`respiratory score

15

4.14.SSA

SSA

4

4.15.MRSS

MRSS

6

MRSS

6

4.16.Health Relative Quality of Life

SHAQ

疼痛10 胃肠问题30 呼吸问题20 雷诺30 指端溃疡0 总体影响50

SHAQ

疼痛10 胃肠问题30 呼吸问题20 雷诺30 指端溃疡0 总体影响50

5.Follow-up 1

urine routine test

正常

other blood test

未见异常

physical examination and take photos

1.Blood routine test

blood routine test

正常

6.Follow-up 2

blood routine test

正常

urine routine test

未见异常

other blood test

未见异常

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

无不良反应

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers