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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:40;胃肠问题:60;呼吸:45;雷诺:50;溃疡:0;总体影响:50

digital ulcer burden

0

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

已婚

Monthly per capita household income

5000 RMB

weight

54 kg

height

156 cm

gender

age

50

nation

place of residence

广东省周边

occupation

自由职业

degree of education

中学

2.3.Physical examination

physical examination

normal

physical examination and take photos

2.4.Blood Routine Tests

normal

2.5.urine routine test

normal

negative

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

正常

2.7.Renel Function Test

renal function

正常

2.8.Image Examinations

Lung CT

ILD

pulmonary CT

ILD

2.13.SSA

SSA

15

2.14.MRSS

MRSS

16

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

35

3.In the process of the treatment

other drugs

硝苯地平

3.1.Treatment Record

medicine

baricitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

digital ulcer burden

0

physical examination

正常

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

renal function test

正常

other blood tests

未见异常

4.10.Image Examinations

Lung CT

ILD

4.13.Lung Function Examination

St.George`respiratory score

25

4.14.SSA

SSA

10

4.15.MRSS

MRSS

8

MRSS

8

4.16.Health Relative Quality of Life

SHAQ

疼痛40 胃肠问题60 呼吸问题20 雷诺50 指端溃疡0 总体影响50

SHAQ

疼痛40 胃肠问题60 呼吸问题20 雷诺50 指端溃疡0 总体影响50

5.Follow-up 1

urine routine test

正常

other blood test

未见异常

physical examination and take photos

1.Blood routine test

blood routine test

正常

6.Follow-up 2

blood routine test

正常

urine routine test

未见异常

other blood test

未见异常

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

2020年7月份出现带状疱疹

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers