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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:0;消化系统:15;呼吸:10;雷诺:40;溃疡:0;总体25

digital ulcer burden

0

negative

2.2.General information

drinking

NO

Smoking history

NO

Marital status

已婚

Monthly per capita household income

5000 RMB

weight

42 kg

height

156 cm

gender

age

36

nation

place of residence

广州

occupation

待业

degree of education

中专

2.3.Physical examination

physical examination and take photos

physical examination

normal

2.4.Blood Routine Tests

normal

2.5.urine routine test

normal

negative

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

2.7.Renel Function Test

renal function

2.8.Image Examinations

Lung CT

pulmonary CT

ILD

2.13.SSA

SSA

2.14.MRSS

MRSS

5

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

5

3.In the process of the treatment

other drugs

泼尼松片

3.1.Treatment Record

medicine

tofacitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

digital ulcer burden

0

physical examination

正常

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

renal function test

正常

other blood tests

未见异常

4.10.Image Examinations

Lung CT

ILD

4.13.Lung Function Examination

St.George`respiratory score

3

4.14.SSA

SSA

5

4.15.MRSS

MRSS

2

MRSS

2

4.16.Health Relative Quality of Life

SHAQ

疼痛0 胃肠问题0 呼吸问题0 雷诺40 指端溃疡0 总体影响10

SHAQ

疼痛0 胃肠问题0 呼吸问题0 雷诺40 指端溃疡0 总体影响10

5.Follow-up 1

urine routine test

正常

other blood test

未见异常

physical examination and take photos

1.Blood routine test

blood routine test

正常

6.Follow-up 2

blood routine test

正常

urine routine test

未见异常

other blood test

未见异常

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

无不良反应

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers