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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:99;消化系统:40;呼吸:70;雷诺:70;溃疡:99;总体影响99

digital ulcer burden

8

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

已婚

Monthly per capita household income

2000 RMB

weight

45 kg

height

155 cm

gender

age

33

occupation

务农

degree of education

小学

place of residence

广东省周边农村

nation

2.3.Physical examination

physical examination and take photos

physical examination

normal

2.4.Blood Routine Tests

normal

2.5.urine routine test

normal

negative

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

正常

2.7.Renel Function Test

renal function

正常

2.8.Image Examinations

Lung CT

未检查

pulmonary CT

未检查

2.13.SSA

SSA

14

2.14.MRSS

MRSS

22

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

34

3.In the process of the treatment

other drugs

氯吡格雷

3.1.Treatment Record

medicine

tofacitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

physical examination

正常

digital ulcer burden

3

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

renal function test

正常

other blood tests

未见异常

4.10.Image Examinations

Lung CT

未检查

4.13.Lung Function Examination

St.George`respiratory score

15

4.14.SSA

SSA

11

4.15.MRSS

MRSS

18

MRSS

18

4.16.Health Relative Quality of Life

SHAQ

疼痛50 胃肠问题30 呼吸问题40 雷诺60 指端溃疡70 总体影响70

SHAQ

疼痛50 胃肠问题30 呼吸问题40 雷诺60 指端溃疡70 总体影响70

5.Follow-up 1

other blood test

未见异常

physical examination and take photos

urine routine test

正常

1.Blood routine test

blood routine test

正常

6.Follow-up 2

urine routine test

other blood test

blood routine test

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

未见不良反应

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers