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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

yes

2.Baseline

SHAQ

疼痛:40;胃肠问题:60;呼吸:75;雷诺:70;溃疡:50;总体影响:80

digital ulcer burden

0

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

已婚

Monthly per capita household income

2000 RMB

weight

52.5 kg

height

170 cm

gender

age

61

nation

place of residence

贵州

occupation

务农

degree of education

中学

2.3.Physical examination

physical examination and take photos

physical examination

abnormal

2.4.Blood Routine Tests

abnormal

2.5.urine routine test

abnormal

positive

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

转氨酶升高

2.7.Renel Function Test

renal function

肌酐、尿素氮、尿酸偏高

2.8.Image Examinations

Lung CT

ILD

pulmonary CT

ILD

2.13.SSA

SSA

16

2.14.MRSS

MRSS

50

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

71分

3.In the process of the treatment

other drugs

3.1.Treatment Record

medicine

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

digital ulcer burden

physical examination

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

4.5.urine routine test

urine routine test

4.6.Liver Function Tests

Hepatobiliary enzymes

4.8.Renel Function Test

renal function test

other blood tests

4.10.Image Examinations

Lung CT

4.13.Lung Function Examination

St.George`respiratory score

4.14.SSA

SSA

4.15.MRSS

MRSS

MRSS

4.16.Health Relative Quality of Life

SHAQ

SHAQ

5.Follow-up 1

urine routine test

other blood test

physical examination and take photos

1.Blood routine test

blood routine test

6.Follow-up 2

blood routine test

urine routine test

other blood test

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers