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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

yes

age≥18 years old

yes

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:60;胃肠问题:20;呼吸:60;雷诺:60;溃疡:65;总体影响:65

digital ulcer burden

2

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

已婚

Monthly per capita household income

3000 RMB

weight

53 kg

height

158 cm

gender

age

38

occupation

待业

degree of education

中学

place of residence

广东佛山

nation

2.3.Physical examination

physical examination and take photos

physical examination

normal

2.4.Blood Routine Tests

normal

2.5.urine routine test

negative

normal

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

正常

2.7.Renel Function Test

renal function

正常

2.8.Image Examinations

Lung CT

ILD

pulmonary CT

ILD

2.13.SSA

SSA

28

2.14.MRSS

MRSS

28

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

59

3.In the process of the treatment

other drugs

硝苯地平 泼尼松片

3.1.Treatment Record

medicine

tofacitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

physical examination

左手食指远端缺损

digital ulcer burden

0

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

renal function test

正常

other blood tests

未见明显异常

4.10.Image Examinations

Lung CT

ILD

4.13.Lung Function Examination

St.George`respiratory score

10

4.14.SSA

SSA

12

4.15.MRSS

MRSS

10

MRSS

10

4.16.Health Relative Quality of Life

SHAQ

疼痛0 胃肠问题0 呼吸问题20 雷诺20 指端溃疡1 总体影响10

SHAQ

疼痛0 胃肠问题0 呼吸问题20 雷诺20 指端溃疡1 总体影响10

5.Follow-up 1

other blood test

未见异常

physical examination and take photos

urine routine test

正常

1.Blood routine test

blood routine test

正常

6.Follow-up 2

urine routine test

other blood test

blood routine test

physical examination and take photos

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

未见不良反应

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers