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1.Screening
1.1.Management for Progress
1.1.1.1.1.1、Character of name

SZD

1.1.1.1.1.2、test number

51

1.1.1.1.1.3、Entering time

2019/11/01 (YYYY/MM/DD)

1.2.Inclusion Criteria

aspirin related small intestinal mucosal injury
/
agree with the research plan
/
sign the informed consent
1.3.Exclusion Criteria

contradications of MCCE
/
GI tract obstruction,or pregnant woman,or abdominal operation history, or can not undertake abdominal operation
/
taking drugs that influencing the test during the past one month
/
taking other antiplatelet or anticoagulant drugs
/
GI tumor or IBD diagnosed by MCCE
/
allergy to aspirin, lactobacillus, PEG,or high polymer material
2.Baseline
2.1.Management of the progress
2.2.General information
2.2.2.2.2.1、Basic information

2.2.2.2.2.2、Past history

高血压、糖尿病

2.2.2.2.2.3、GSRS

0

2.3.First result of MCCE
2.2.3.2.3.1、Gastric injury Lanza score

4

2.2.3.2.3.2、Time of gastric examination

20 min

2.2.3.2.3.3、Other result of stomach

胃体溃疡

2.2.3.2.3.4、Small intestine injury score

4

2.2.3.2.3.5、Time of small intestine examination

200 min

2.2.3.2.3.6、Other result of small intestine

回肠溃疡

2.2.3.2.3.7、Whether or not to complete the smll intestine test

yes
2.2.3.2.3.8、Time of passing out the capsule

hour

2.2.3.2.3.9、Side effect of bowel preparation

无

2.2.3.2.3.10、Side effect of MCCE

无

2.4.Result of blood tests
2.2.4.2.4.1、Inflammatory cytokines

2.2.4.2.4.2、Others

2.5.Result of stool microbiota test
2.2.5.2.5.1、Phylum level

Actinobacteria 8.57 Ascomycota 0 Bacteroidetes 36.81 Euryarchaeota 0 Firmicutes 12.9 Fusobacteria 0 Proteobacteria 41.72 Synergistetes 0 Verrucomicrobia 0 Viruses_noname 0 others 0

2.2.5.2.5.2、Class level

Actinobacteria 8.21 Bacilli 2.42 Bacteroidia 31.63 Betaproteobacteria 0.2 Clostridia 9.51 Deltaproteobacteria 0 Erysipelotrichia 0 Gammaproteobacteria 46.78 Negativicutes 1.25 Verrucomicrobiae 0 others 0

2.2.5.2.5.3、Order level

Bacteroidales 31.08 Bifidobacteriales 4.55 Burkholderiales 0.26 Clostridiales 10.16 Coriobacteriales 0.08 Desulfovibrionales 0 Enterobacteriales 50.88 Lactobacillales 1.76 Selenomonadales 1.23 Verrucomicrobiales 0 others 0

2.2.5.2.5.4、Family level

Bacteroidaceae 38.16 Bifidobacteriaceae 4 Enterobacteriaceae 44.76 Eubacteriaceae 2.13 Lachnospiraceae 0.73 Porphyromonadaceae 0 Prevotellaceae 0 Rikenellaceae 0 Ruminococcaceae 6.74 Veillonellaceae 1.27 others 2.22

2.2.5.2.5.5、Genus level

Alistipes 0 Bacteroides 35.32 Bifidobacterium 4.37 Escherichia 46.72 Eubacterium 2.19 Faecalibacterium 4.88 Parabacteroides 0 Prevotella 0 Roseburia 0.08 Subdoligranulum 0.21 others 6.21

2.2.5.2.5.6、Specie level

Bacteroides_coprocola 0 Bacteroides_dorei 14.36 Bacteroides_ovatus 8.47 Bacteroides_plebeius 0 Bacteroides_stercoris 0 Bacteroides_vulgatus 0 Escherichia_coli 36.49 Eubacterium_rectale 1.48 Faecalibacterium_prausnitzii 4.54 Prevotella_copri 0 others 34.65

2.2.5.2.5.7、Functional gene

2.2.5.2.5.8、Functional pathway

2.2.5.2.5.9、Data of stool microbiata

2.6.Others

3.In the process of the treatment
3.1.Whether or not to enter the test and group

Lactobacillus group
3.2.Primary symptom

3.3.Using other drugs

3.4.Side effect

无

3.5.Others

4.At the end of the treatment
4.1.Whether or not to exit

Complete the research
4.2.GSRS after treatmrnt

4.3.Sceond result of MCCE
4.4.3.4.3.1、Gastric injury Lanza score

4

4.4.3.4.3.2、Time of gastric examination

20 min

4.4.3.4.3.3、Other result of stomach

无

4.4.3.4.3.4、Small intestine injury score

4

4.4.3.4.3.5、Time of small intestine examination

560 min

4.4.3.4.3.6、Other result of small intestine

无

4.4.3.4.3.7、Whether or not to complete the smll intestine test

4.4.3.4.3.8、Time of passing out the capsule

hour

4.4.3.4.3.9、Side effect of bowel preparation
4.4.3.4.3.10、Side effect of MCCE

无

4.4.Result of blood tests after treatment
4.4.4.4.4.1、Inflammatory cytokines

4.4.4.4.4.2、Others

4.5.Result of stool microbiota test after treatment
4.4.5.4.5.1、Phylum level

Actinobacteria 22.04 Ascomycota 0 Bacteroidetes 18.88 Euryarchaeota 0 Firmicutes 20.19 Fusobacteria 0 Proteobacteria 38.89 Synergistetes 0 Verrucomicrobia 0 Viruses_noname 0 others 0

4.4.5.4.5.2、Class level

Actinobacteria 20.89 Bacilli 10.2 Bacteroidia 16.02 Betaproteobacteria 0.15 Clostridia 5.95 Deltaproteobacteria 0 Erysipelotrichia 0 Gammaproteobacteria 43.12 Negativicutes 3.67 Verrucomicrobiae 0 others 0

4.4.5.4.5.3、Order level

Bacteroidales 17.13 Bifidobacteriales 12.71 Burkholderiales 0.21 Clostridiales 6.91 Coriobacteriales 0.01 Desulfovibrionales 0 Enterobacteriales 51 Lactobacillales 8.09 Selenomonadales 3.92 Verrucomicrobiales 0 others 0.02

4.4.5.4.5.4、Family level

Bacteroidaceae 22 Bifidobacteriaceae 11.7 Enterobacteriaceae 46.94 Eubacteriaceae 1.26 Lachnospiraceae 0.58 Porphyromonadaceae 0 Prevotellaceae 0 Rikenellaceae 0 Ruminococcaceae 5.3 Veillonellaceae 4.24 others 7.97

4.4.5.4.5.5、Genus level

Alistipes 0 Bacteroides 20.08 Bifidobacterium 12.61 Escherichia 45.98 Eubacterium 1.28 Faecalibacterium 3.82 Parabacteroides 0 Prevotella 0 Roseburia 0.12 Subdoligranulum 0.26 others 15.85

4.4.5.4.5.6、Specie level

Bacteroides_coprocola 0 Bacteroides_dorei 7.61 Bacteroides_ovatus 7.44 Bacteroides_plebeius 0 Bacteroides_stercoris 0 Bacteroides_vulgatus 0 Escherichia_coli 28.63 Eubacterium_rectale 1.02 Faecalibacterium_prausnitzii 3.6 Prevotella_copri 0 others 51.7

4.4.5.4.5.7、Functional gene

4.4.5.4.5.8、Functional pathway

4.4.5.4.5.9、Data of stool microbiata

4.6.Others after treatment

5.Logging data
5.1.Keyboarder

孙亚梅

5.2.Time of logging

2020/07/29 (YYYY/MM/DD)

6.Speciman management system
7.Data management system
8.ADR/ADE management system
9.Madicine management system
10.Research team
10.1.Researchers
11.Design, Methods
11.1.Calculation of sample size

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