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1.Screening
1.1.Management for Progress

yes

1.2.Inclusion Criteria

yes

age≥18 years old

1.3.Exclusion Criteria

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

NO

1.4.Exit or termination criteria

NO

NO

NO

NO

2.Baseline

SHAQ

疼痛:80;胃肠问题:80;呼吸:60;雷诺:40;溃疡:50;总体影响80

digital ulcer burden

0

positive

2.2.General information

drinking

NO

Smoking history

NO

Marital status

未婚

Monthly per capita household income

3000 RMB

weight

48 kg

height

160 cm

gender

age

27

nation

occupation

公司职员

degree of education

大学

place of residence

广东佛山

2.3.Physical examination

physical examination and take photos

physical examination

normal

2.4.Blood Routine Tests

normal

2.5.urine routine test

negative

normal

2.6.Serum Liver Function Tests

Hepatobiliary enzymes

正常

2.7.Renel Function Test

renal function

正常

2.8.Image Examinations

Lung CT

ILD

pulmonary CT

ILD

2.13.SSA

SSA

12

2.14.MRSS

MRSS

24

2.15.Lung Function Examination

ST.George`s Respiratory Questionnaire sore

48

3.In the process of the treatment

other drugs

前列地尔

3.1.Treatment Record

medicine

baricitinib

4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination

digital ulcer burden

0

physical examination

正常

physical examination and take photos

4.3.Blood Routine Tests

blood routine test

正常

4.5.urine routine test

urine routine test

正常

4.6.Liver Function Tests

Hepatobiliary enzymes

正常

4.8.Renel Function Test

other blood tests

未见异常

renal function test

正常

4.10.Image Examinations

Lung CT

ILD

4.13.Lung Function Examination

St.George`respiratory score

46

4.14.SSA

SSA

10

4.15.MRSS

MRSS

18

MRSS

18

4.16.Health Relative Quality of Life

SHAQ

疼痛20 胃肠问题80 呼吸问题40 雷诺10 指端溃疡30 总体影响60

SHAQ

疼痛20 胃肠问题80 呼吸问题40 雷诺10 指端溃疡30 总体影响60

5.Follow-up 1

urine routine test

正常

other blood test

未见异常

physical examination and take photos

1.Blood routine test

blood routine test

正常

6.Follow-up 2

other blood test

未见异常

physical examination and take photos

urine routine test

未见异常

blood routine test

正常

8.Management system of participants
10.Data management system
11.ADR/ADE management system

adverse reactions

未见不良反应

15.Research team
15.1.Institutions

institutions

15.2.Researchers

researchers