- Screening
- Preoperative indications
- Intraoperative indications
- Follow-up one week after aspiration
- Adverse events
- Follow-up 2
- Follow-up 3
- Management system of participants
- Speciman management system
- Data management system
- ADR/ADE management system
- Madicine management system
- Instruments management system
- SOPs
- Research team
- Design, Methods
|
Age ≥ 18 years old | Yes
|
|
Thyroid US indicates thyroid nodule. | Yes
|
|
US assessment accords with FNA criteria recommended by C-TIRADS | Yes
/No
|
|
nodule with high insufficient rate | high cystic nodule
|
|
Informed consent | Yes
|
|
Allergic to lidocaine or SonoVue | No
|
|
Refuse to CEUS | No
|
|
Severe abnormality of heart function or lung function | No
|
|
Severe abnormality of coagulation function | No
|
|
Pregnancy | No
|
|
Active infectious focus on cervical skin | No
|
|
Patients unable to cooperate for FNA or CEUS | No
|
|
Registration number | 0004026229 |
|
Birthday | 1956-03-03 |
|
Sex | Female
|
|
Telephone | 18023817309 |
|
Date for signing informed consent | 2023-05-23 |
|
Location of target thyroid nodule | left lobe
|
|
transverse diameter | 40 mm |
|
Anteroposterior diameter | 30 mm |
|
Upper and lower diameter | 42 mm |
|
Solid component (%) | 5 |
|
echo | iso-echo
|
|
edge | clear
|
|
border | regular
|
|
acoustic halo | No
|
|
Strong echo within nodule | No
|
|
Solid component of sheet-like strong echo (%) | - |
|
Score of ACR TI-RADS | 2 |
|
Rank of ACR TI-RADS | 2 |
|
Score of C-TIRADS | 0 |
|
Rank of C-TIRADS | 3 |
|
Ultrasonic diagnose | 良性结节 |
|
VCs function evaluated by TLUSG | bilateral VCs moved symmetrically
|
|
Routine blood test | Yes
|
|
Coagulation function | Yes
|
- Time of aspiration
- Contrast-enhance indication (CEUS-FNA group)
- Progression of operation
- Intraoperative instant complication
|
Date of aspiration | 2023-05-23 |
|
Start time |
|
|
End time |
|
|
Dosage of SonoVue | - |
|
No enhancement | No
|
|
Ratio of enhancement | - |
|
Injection of SonoVue during FNA | No
|
|
Machine | GE logiq E20
|
|
Local anesthesia | 2% lidocaine
|
|
other local anaesthesics | - |
|
Dosage of local anaesthesics | 5 ml |
|
Patient compliance | good
|
|
Aspiration needle | 25G
|
|
FNA approach | lateral approach
|
|
Aspiration times | 4 |
|
Use of negative pressure | No
|
|
Pressure | - ml |
|
Quality of nodule | Soft
|
|
Grittiness | No
|
|
Sample capacity | much
|
|
Allergic to contrast agent | No
|
|
Painful | No
|
|
VAS score | - |
|
Analgesic | No
|
|
Painful when leave interventional room | No
|
|
Haemorrhage | No
|
|
Voice change | No
|
|
Vagal nerve syndrome | No
|
|
Horner syndrome | No
|
|
Aspiration related acute hypersensitivity reaction | No
|
|
location | subcapsular
|
|
visible for bleeding by CDFI | no
|
|
extend of hematoma (once after FNA) | 7*11*8 |
|
methods | pressure hemostasis
|
|
visible hemorrhage by CDFI 30 minutes after FNA | no
|
|
extend of hematoma (before patient departure) | |
|
appearance | |
|
vocal cord mobility assessment by ultrasound | |
|
methods | |
|
whether the voice recovers when the patient leaves |
|
Pathological number |
|
|
Whether sample capacity is enough | |
|
Number of observable follicular epithelial cell clusters in specimen | |
|
Cytopathology classification |