- Inclusion Criteria
- Exclusion Criteria
- Criteria for dropout/withdrawal cases
- Exclusion criteria for cases
|
Age 60-80 years old, gender unlimited； | Yes
|
|
Patients undergoing gastrointestinal surgery under selective tracheal intubation and general anesthesia; Duration of operation 4h; | Yes
|
|
ASA grades Ⅱ to Ⅲ | Yes
|
|
BMI 18-30kg/m2 | Yes
|
|
Voluntarily sign informed consent | Yes
|
|
Being deaf and mute, she is unable to communicate verbally | No
|
|
Patients with difficult airway were modified for Mallampati grade IV | No
|
|
Preoperative delirium or dementia | No
|
|
Preoperative history of severe cardiovascular disease and uncontrollable diabetes; Serious injury or disease of vital organs such as the lungs, brain, liver or kidneys | No
|
|
Patients with severe consciousness disorder or mental system disease (schizophrenia, mania, insanity, etc.) and cognitive dysfunction | No
|
|
Intolerance or allergy to benzodiazepines | No
|
|
A history of alcoholism; And a history of drug addiction or other substance abuse | No
|
|
The patient voluntarily withdrew the informed consent | No
|
|
No follow-up, no efficacy and safety data were collected | No
|
|
The investigator ordered them to withdraw: patients with unanticipated difficulty with mask ventilation or tracheal intubation | No
|
|
Violation of the entry standard | No
|
|
Inadequate or missing medical records | No
|
|
Age | 70 岁 |
|
Gender | 1 |
|
Height | 168 cm |
|
Weight | 60 kg |
|
Body mass index | 21.4 kg/m2 |
|
ASA classification | Ⅲ 级 |
|
Underlying disease | 0 |
|
hypertension | No
|
|
diabetes | No
|
|
Surgical name | 腹腔镜下胃病损切除术 |
- systolic pressure
- diastolic pressure
- Heart rate
- Bispectral index
- Operation duration
- The infusion speed for maintaining general anesthesia with relevant drugs
|
Baseline | 130 mmHg |
|
Induction time | 126 mmHg |
|
3 minutes after administration | 122 mmHg |
|
Immediately after intubation | 127 mmHg |
|
10 minutes after administration | 121 mmHg |
|
Baseline | 75 mmHg |
|
Induction time | 73 mmHg |
|
3min after administration | 69 |
|
Immediately after intubation | 67 mmHg |
|
10min after administration | 69 mmHg |
|
Baseline | 71 次/分 |
|
Induction time | 73 次/分 |
|
3min after administration | 72 次/分 |
|
Immediately after intubation | 77 次/分 |
|
10min after administration | 78 次/分 |
|
Baseline | 93 |
|
Induction time | 75 |
|
3min after administration | 60 |
|
5min after administration | 62 |
|
10min after administration | 55 |
|
Operation duration | 4 H |
|
The infusion speed for maintaining general anesthesia with relevant drugs | 0.8 mg/kg/h |
|
The infusion speed maintained by remifentanil general anesthesia | 0.5 ug/kg/min |
|
The average infusion rate maintained by general anesthesia with norepinephrine | 0 ug/kg/h |
- The time of onset of sedation until loss of consci
- Occurrence of adverse reactions during induction
- Induction success rate of general anesthesia
- Total Drug Usage
- Quality of Awakening
- The correlation between remazolam and bis
|
The time of onset of sedation until loss of consciousness | 30 s |
|
Hypotension (systolic blood pressure <90mmHg, or a decrease of more than 20% from baseline） | 0 次 |
|
Bradycardia (heart rate <50 beats/min) | 0 次 |
|
Injection pain | No
|
|
General anesthesia induction successful | Yes
|
|
Total use of the vasoactive drug deoxyadrenaline during induction | 0 ug |
|
Total norepinephrine use during maintenance of general anesthesia | 0 mg |
|
Total usage of Remazolam | 210 mg |
|
Total use of propofol | 0 mg |
|
Total use of remifentanil | 8 mg |
|
Whether agitation occurs during the wake perio | No
|
|
extubation time | 20 min |
|
PACU stay time | 30 min |
|
T0（Baseline） bis value | 93 |
|
T1（induction time）bis value | 75 |
|
T2(5min after induction)bis value | 62 |
|
T3 (10min after induction)bis value | 55 |
|
T4(at the end of the operation) bis value | 65 |
|
T5（The lowest) bis value | 55 |
- Recovery quality assessment
- Incidence of nausea and vomiting
- Pain measurement
- Incidence of delirium
- Onset and duration of delirium
|
Concise Mental State Scale Score | 24 分 |
|
Total score of qor-40 scale | 84 分 |
|
Emotional state score | 19 分 |
|
Physical Comfort Score | 22 分 |
|
Psychological support score | 25 分 |
|
Self-care score | 11 分 |
|
pain score | 7 分 |
|
The frequency of nausea within three days after surgery | 0 次 |
|
The frequency of vomiting within three days after surgery | 0 次 |
|
24h postoperative pain numerical score | 3 分 |
|
48h postoperative pain numerical score | 2 分 |
|
72h postoperative pain numerical score | 1 分 |
|
Occurrence of delirium 24 hours after surgery（3D-CAM scale） | No
|
|
Occurrence of delirium 48 hours after surgery（3D-CAM scale） | No
|
|
Occurrence of delirium 72h after surgery(3D-CAM scale） | No
|
|
Occurrence of delirium 96h after surgery | Yes
/No
|
|
Occurrence of delirium 120h after surgery | No
|
|
Time of onset of delirium | 0 day |
|
Duration of delirium | 0 day |