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1.Screening
1.1.Inclusion Criteria

Age ≥ 65 years

Yes

ASA Classification II-III

Yes

3D-CAM method to determine the absence of pre-existing delirium before surgery

Yes

Score ≥15 on the Brief Mental State Examination scale

Yes

1.2.Exclusion Criteria

Previous history of neurological or psychiatric disorders

Long-term use of sedative-hypnotic, antipsychotic drugs

Severe visual and hearing impairment

Combined heart, lung, liver, kidney and other vital organ dysfunction

2.Baseline
2.1.General information

Type of surgery

Rectal Cancer Surgery

genders

female

age

70

Length of education

5

BMI

27.34

ASA classification

III

MMSE scores

23

smoking history

No

drinking history

No

Number of preoperative chemotherapy treatments

3

high blood pressure

No

diabetes

No

coronary heart disease

No

Preoperative hemoglobin

125 g/L

Preoperative albumin

39.6 g/L

Preoperative SII

539.02

3.In the process of the treatment
3.1.Intraoperative information

Surgical time

178 min

propofol

1350 mg

cis-Atracurium

16 mg

sufentanil

50 ug

remifentanil

1.000 mg

Ephedrine

21 mg

Atropine

0 mg

Urapidil

0 mg

red blood cell suspension

0 U

Plasma transfusion

0 ml

fluid infusion

2000 ml

hemorrhage

50 ml

urine output

200 ml

Average CSI value

Duration of EEG burst suppression

64 s

Preoperative MAP T0

90 mmHg

Preoperative heart rate T0

62 次/分

Pre-induction MAP T1

94 mmHg

Pre-induction heart rate T1

66 次/分

Post-induction MAP T2

58 mmHg

Post-induction heart rate T2

58 次/分

Average MAP T3

102 mmHg

Average heart rate T3

73 次/分

Out of the operating room MAP T4

108 mmHg

Heart rate out of the operating room T4

59 次/分

4.At the end of the treatment
4.1.Post-operative information

Extraction time

10 min

PACU dwell time

85 min

Days of hospitalization

13

Arrhythmia/Heart Failure/Heart Attack

No

cutaneous infection

No

lung infection

No

nausea and vomiting

No

DVT/PTE

No

Postoperative day one SII

806.83

Postoperative day three SII

607.65

Postoperative day five SII

903.43

5.Follow-up 1
5.1.5-day post-treatment visit

POD on the first postoperative day

No

POD on the second day postoperatively

No

POD on the third postoperative day

Yes

POD on the fourth postoperative day

No

POD on the fifth postoperative day

No

VAS score on the first day postoperatively

5

VAS score on the second day after surgery

3

VAS score on the third postoperative day

3

VAS score on the fourth postoperative day

2

VAS score on the fifth postoperative day

2