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1.Screening
1.1.Inclusion Criteria

Age ≥ 65 years

Yes

ASA Classification II-III

Yes

3D-CAM method to determine the absence of pre-existing delirium before surgery

Yes

Score ≥15 on the Brief Mental State Examination scale

Yes

1.2.Exclusion Criteria

Previous history of neurological or psychiatric disorders

Long-term use of sedative-hypnotic, antipsychotic drugs

Severe visual and hearing impairment

Combined heart, lung, liver, kidney and other vital organ dysfunction

2.Baseline
2.1.General information

Type of surgery

Colon Cancer Surgery

genders

female

age

70

Length of education

5

BMI

22.06

ASA classification

II

MMSE scores

26

smoking history

No

drinking history

No

Number of preoperative chemotherapy treatments

0

high blood pressure

Yes

diabetes

No

coronary heart disease

No

Preoperative hemoglobin

125 g/L

Preoperative albumin

42.7 g/L

Preoperative SII

939.68

3.In the process of the treatment
3.1.Intraoperative information

Surgical time

150 min

propofol

1250 mg

cis-Atracurium

21 mg

sufentanil

45 ug

remifentanil

0.750 mg

Ephedrine

0 mg

Atropine

0 mg

Urapidil

0 mg

red blood cell suspension

0 U

Plasma transfusion

0 ml

fluid infusion

2100 ml

hemorrhage

20 ml

urine output

200 ml

Average CSI value

55

Duration of EEG burst suppression

0 s

Preoperative MAP T0

78 mmHg

Preoperative heart rate T0

73 次/分

Pre-induction MAP T1

91 mmHg

Pre-induction heart rate T1

66 次/分

Post-induction MAP T2

82 mmHg

Post-induction heart rate T2

67 次/分

Average MAP T3

85 mmHg

Average heart rate T3

53 次/分

Out of the operating room MAP T4

67 mmHg

Heart rate out of the operating room T4

74 次/分

4.At the end of the treatment
4.1.Post-operative information

Extraction time

9 min

PACU dwell time

50 min

Days of hospitalization

11

Arrhythmia/Heart Failure/Heart Attack

No

cutaneous infection

No

lung infection

No

nausea and vomiting

No

DVT/PTE

No

Postoperative day one SII

2796.44

Postoperative day three SII

2003.78

Postoperative day five SII

1641.82

5.Follow-up 1
5.1.5-day post-treatment visit

POD on the first postoperative day

No

POD on the second day postoperatively

No

POD on the third postoperative day

No

POD on the fourth postoperative day

No

POD on the fifth postoperative day

No

VAS score on the first day postoperatively

1

VAS score on the second day after surgery

1

VAS score on the third postoperative day

1

VAS score on the fourth postoperative day

1

VAS score on the fifth postoperative day

0