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1.Screening
1.1.Inclusion Criteria

Age ≥ 65 years

Yes

ASA Classification II-III

Yes

3D-CAM method to determine the absence of pre-existing delirium before surgery

Yes

Score ≥15 on the Brief Mental State Examination scale

Yes

1.2.Exclusion Criteria

Previous history of neurological or psychiatric disorders

Long-term use of sedative-hypnotic, antipsychotic drugs

Severe visual and hearing impairment

Combined heart, lung, liver, kidney and other vital organ dysfunction

2.Baseline
2.1.General information

Type of surgery

Rectal Cancer Surgery

genders

male

age

77

Length of education

6

BMI

27.34

ASA classification

III

MMSE scores

22

smoking history

Yes

drinking history

Yes

Number of preoperative chemotherapy treatments

0

high blood pressure

No

diabetes

No

coronary heart disease

No

Preoperative hemoglobin

123 g/L

Preoperative albumin

35.5 g/L

Preoperative SII

717.68

3.In the process of the treatment
3.1.Intraoperative information

Surgical time

150 min

propofol

1000 mg

cis-Atracurium

21 mg

sufentanil

50.0 ug

remifentanil

1.500 mg

Ephedrine

6 mg

Atropine

0.3 mg

Urapidil

0 mg

red blood cell suspension

0 U

Plasma transfusion

0 ml

fluid infusion

2100 ml

hemorrhage

50 ml

urine output

500 ml

Average CSI value

50

Duration of EEG burst suppression

196 s

Preoperative MAP T0

81 mmHg

Preoperative heart rate T0

78 次/分

Pre-induction MAP T1

80 mmHg

Pre-induction heart rate T1

75 次/分

Post-induction MAP T2

84 mmHg

Post-induction heart rate T2

49 次/分

Average MAP T3

100 mmHg

Average heart rate T3

55 次/分

Out of the operating room MAP T4

89 mmHg

Heart rate out of the operating room T4

72 次/分

4.At the end of the treatment
4.1.Post-operative information

Extraction time

min

PACU dwell time

min

Days of hospitalization

Arrhythmia/Heart Failure/Heart Attack

cutaneous infection

lung infection

nausea and vomiting

DVT/PTE

Postoperative day one SII

Postoperative day three SII

Postoperative day five SII

5.Follow-up 1
5.1.5-day post-treatment visit

POD on the first postoperative day

POD on the second day postoperatively

POD on the third postoperative day

POD on the fourth postoperative day

POD on the fifth postoperative day

VAS score on the first day postoperatively

VAS score on the second day after surgery

VAS score on the third postoperative day

VAS score on the fourth postoperative day

VAS score on the fifth postoperative day