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1.Inclusion Criteria& Exclusion Criteria
1.1.Inclusion criteria

Age

67

Patients with tumors located in the supraorbital notch are scheduled for cranial neurosurgery at an appropriate time

Yes

American Society of Anesthesiologists (ASA) physical status of I-III

ASA II

The patient is conscious and cooperative prior to surgery and can provide informed consent

Yes

1.2.Exclusion criteria

known hypersensitivity to local anaesthetics (liposomal bupivacaine, ropivacaine), nonsteroidal anti-inflammatory drugs and opioids (NSAIDs), or opioids

No

history of chronic headache

No

severe pulmonary disease, hepatic or renal insufficiency

No

pre-existing coagulopathy

No

infection at the block injection sites

No

significant cognitive impairment

No

concurrent participation in another interventional clinical trial

No

refusal to participate

No

2.Baseline indexes
2.1.Age

2.2.sex

2.3.Body Mass Index (BMI)

2.4.ASA physical status

2.5.HR admission,

次/分

2.6.MAP admission,

mmHg

2.7.Preoperative complication

2.8.tumor characteristics
2.2.8.2.8.1、Tumor site

2.2.8.2.8.2、Tumor size

2.2.8.2.8.3、Tumor classfication

2.9.Treatment

3.Intraoperative data
3.1.Intraoperative drug dosage
3.3.1.3.1.1、sevoflurane

mL

mL

3.3.1.3.1.2、ciprofol

mg

3.3.1.3.1.3、rocuronium

mg

3.2.Fluid balance
3.3.2.3.2.1、Blood loss

mL

3.3.2.3.2.2、Urine volume

mL

3.3.2.3.2.3、Total volume of infused fluid

mL

3.3.Intraoperative findings
3.3.3.3.3.1、Use of vasopressor

3.3.3.3.3.2、Intraoperative hypertension

3.3.3.3.3.3、Bradycardia

3.4.Time
3.3.4.3.4.1、Duration of anesthesia

min

3.3.4.3.4.2、Duration of surgery

min

4.Primary outcome
4.1.Numeric Rating Scale (NRS)-" pain at rest"

PACU

24 hours after surgery

48 hours after surgery

72 hours after surgery

4.2.Numeric Rating Scale (NRS)-"worst pain "

PACU

24 hours after surgery

48 hours after surgery

72 hours after surgery

5.Secondary outcomes
5.1.Haemodynamic stability
5.5.1.5.1.1、△HR

skin incision

BPM

skin closure

BPM

head pinning

BPM

5.5.1.5.1.2、△MAP

skin incision

mmHg

skin closure

mmHg

head pinning

mmHg

5.2.Total consumption of intraoperative fentanyl and postoperative rescue propacetamol

Total intraoperative fentanyl consumption

mg

Postoperative dose of propamol

g

5.3.Length of hospital stay

days

5.4.Inflammatory response

CRP

mg/mL

5.5.Adverse events